利用单通道刺激仪建立家兔WPW综合征模型  

Wolff-Parkinson-White syndrome rabbit model constructed with single channel stimulation instrument

作　　者：徐兆龙[1] 刘仁光[1] 

机构地区：[1]辽宁医学院附属第一医院心血管病研究所,辽宁锦州121001

出　　处：《中国心脏起搏与心电生理杂志》2012年第2期146-148,共3页Chinese Journal of Cardiac Pacing and Electrophysiology

基　　金：辽宁省教委基金资助(项目编号:20072105)

摘　　要：目的探索利用单通道刺激仪建立WPW综合征动物模型的可行性。方法取10只健康大耳白兔,采用单通道刺激仪,于高位右房及左室前壁房室沟心外膜处分别置放感知电极和刺激电极。用程控早搏S2与P波同步正扫心室(步长5 ms)。对照窦性心搏时PR间期、QRS波形及S1S1起搏心室时QRS波形,观测PS2正扫全程中S2R2初始向量、最大向量和终末向量的变化,及PS2间期与PR间期的差值与S2R2波形变化的关系。结果 10只家兔均可成功模拟WPW综合征心电活动,呈完全心室预激、显性预激(不完全心室预激)、不完全潜在预激及潜在性预激四种QRS波形变化过程。PS2间期<PR间期:二者差值≥47.00±7.53 ms时,S2R2呈完全心室预激QRS波形,二者差值<47.00±7.53 ms时,S2R2呈显性预激QRS波形;PS2间期≥PR间期:二者差值≤13.00±3.50 ms时,S2R2呈不完全潜在预激QRS波形,二者差值>13.00±3.50 ms时,S2R2呈潜在性预激QRS波形。结论利用单通道刺激仪可更加实际地建立WPW综合征模型。Objective To explore the feasibility of constructing a Wolff-Parkinson-White syndrome（WPW） model in rabbit by a single channel stimulator.Methods The electrodes for pacing and sensing were sutured respectively under the high right atrium and the epicardium of anterior wall of left ventricle near the atrioventricular groove in 10 rabbits（to simulate the left anterior bypass）,S2 stimulation was given in sequence with an increasing pace about ＋5 ms when each P wave was sensed.The changes of the initial and the largest and the terminal vector of QRS were measured when S2 stimulation was given,and that were contrasted with the waveform of QRS in sinus rhythm and in the S1S1 stimulation.And the differences between PR interval and PS2 interval and its relationship with the waveform of S2R2 were also observed.Results Four kinds of waveforms of QRS were observed on WPW syndrome rabbit models,which occured as the complete ventricular pre-excitation QRS,the dominant ventricular pre-excitation QRS,the latent incomplete pre-excitation QRS and the latent pre-excitation QRS;The waveform of QRS were decided by bypass conducting time and/ the conducting time difference between the atrioventricular node way and atrioventricular bypass.PS2 intervalPR interval,when the differences between them≥47.00±7.53 ms,S2R2 presents as the complete ventricular pre-excitation QRS;when the differences between them47.00±7.53 ms,S2R2 were the dominant pre-excitation QRS;PS2 interval ≥PR interval,when the differences between them≤13.00±3.50 ms,S2R2 presents as the latent incomplete pre-excitation QRS;when the differences between them13.00±3.50 ms,S2R2 presents as the latent pre-excitation QRS.Conclusions The Wolff-Parkinson-White syndrome rabbit model constructed with single channel stimulation instrument is close to the actrual electrophysiology of pre-excitation.

关 键 词：电生理学 动物模型 WPW综合征 心电描记 

分 类 号：R541.7[医药卫生—心血管疾病] R331.38[医药卫生—内科学]