新生儿血管瘤的高危因素  

Risk factors of infantile hemangiomas

作　　者：王琳[1] 张耀文[2] 米双利 陈杰[1] 张勇[1] 张知新[4] 

机构地区：[1]卫生部中日友好医院预防保健科,北京100029 [2]卫生部中日友好医院感染管理和疾病预防控制办公室,北京100029 [3]中国医学科学院北京基因组研究所重大疾病基因组与个体化医疗实验室 [4]卫生部中日友好医院儿科,北京100029

出　　处：《中华围产医学杂志》2012年第6期349-352,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的探讨新生儿血管瘤发生的高危因素。方法采用调查问卷的方法调查2009年1月1日至2011年12月31日在北京中日友好医院预防保健科建立《母子保健档案》的孕妇及其新生儿，调查内容包括孕母基本信息、围产期因素以及社会经济和环境因素。新生儿体检时若明确诊断血管瘤，对患处进行拍照，记录血管瘤部位及大小。采用单因素和多因素Logistic回归分析新生儿血管瘤的高危因素。结果共回收有效问卷1998份，确诊新生儿血管瘤患儿94例，发生率为4．7％。多因素Logistic回归分析显示，新生儿血管瘤的危险因素为母亲孕龄≥30岁（OR=2．687，95％CI：1．615～4．472，P=0．000）、孕次≥2次（OR=1．730，95％CI：1．032～2．901，P=0．038）、新生儿性别（女）（OR=1．855，95％CI：1．187～2．899，P=0．007）、先兆流产（0R=3．135，95％Cj：1．487～6．609，P=0．003）、羊膜腔穿刺（OR=2．754，95％CI：1．278～5．938，P=0．010）、血管瘤家族史（OR=2．978，95％CI：1．127～4．049，P=0．032）和视频显示终端暴露〉45h／周（OR=3．166，95％CI：2．027～4．944，P=0．000）。结论新生儿血管瘤发生的高危因素可能为母亲年龄、多次妊娠、女婴、先兆流产、羊膜腔穿刺、家族史和长时间视频显示终端暴露。Objective To explore the risk factors for infantile hemangiomas with the emphasis on perinatal factors and socioeconomic and environmental status. Methods A questionnaire survey was carried out targeting mothers and their babies who admitted to the Department of Prevention and Health Care of China-Japan Friendship Hospital for registration from Jan. 1st, 2009 to Dec. 31st, 2011. Information gathered included maternal basic information, perinatal factors before and during pregnancy, and socioeconomic and environmental status. Photos and record of the position and size of the pathological change were taken once infantile hemangiomas were diagnosed. Univariate analysis and multivariate Logistic regression analysis were carried out to investigate the risk factors. Results One thousand nine hundred and ninety-eight questionnaires with detail information were collected, among which 94 infants were diagnosed with infantile hemangiomas （4.7 % ）. It showed that maternal age≥ 30 （OR = 2. 687, 95% CI.. 1. 615-4. 472, P = 0. 000）, multiple pregnancies （OR = 1. 730, 95%CI;1.032-2.901,P=0.038）, female infants （OR=1.855, 95% CI： 1.187-2.899,P=0.007）, threatened abortion （OR = 3. 135, 95% CI： 1. 487-6. 609, P = 0. 003）, amniocentesis （OR = 2. 754, 95%CI; 1. 278-5. 938,P = 0. 010）, family history of hemangiomas （OR = 2. 978, 95% CI： 1. 127- 4. 049,P=0. 032） and video display terminals exposure 〉45 h/week （OR= 3. 166,95%CI：2. 027- 4. 944,P= 0. 000） were closely associated with infantile hemangiomas development. Conclusions The elderly maternal age, multiple pregnancies, female infants, threatened abortion, amniocentesis and family history of infantile hemangiomas and long-time exposure of video display terminals might be the risk factors for infantile hemangiomas.

关 键 词：血管瘤 婴儿 新生 危险因素 

分 类 号：R722.1[医药卫生—儿科]