不同浓度聚桂醇注射后对血管及血栓形成的影响  

Effects of different concentrations of lauromacrogol intravenous injection on thrombosis and vascular wall

作　　者：陈科[1] 陈石海[1] 于海生[1] 齐贺斌[1] 

机构地区：[1]广西医科大学第一附属医院整形美容外科,南宁530021

出　　处：《中华医学美学美容杂志》2012年第3期190-192,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨不同浓度聚社醇静脉注射对血管及血栓形成的影响。方法选择2．5～3．0kg成年家兔作为研究对象。取其耳缘静脉30条，随机分成6组：1．0％聚桂醇组、0．9Vo聚娃醇组、0．8％聚桂醇组、0．7％聚挂醇组、0．6％聚桂醇组以及生理盐水组．每组均为5条血管。分别于注药后1、3、5、7d取不同浓度聚桂醇注射的静脉及其周围组织进行常规HE染色以及免疫组织化学法榆测血管内皮细胞生长因子（VEGF）的表达。结果肉眼观察和HE染色显示，注射后1．0％聚佳醉组、0．9％聚桂醇组、0．8％聚桂醇组、0．7％聚杜醇纽血管内均有血栓形成，0．6％聚桂醇组和生理盐水组注射后血管内无血栓形成；VEGF评分显爪，各时间段1．0％聚桂醇组、0．9％聚桂醇组、0．8％聚棒醇组、0．7％聚替醇组组间对比差异无统计学意义（P〉0．05），各时段各组与0．6％聚挂醇纰对比蓐异有统计学意义（P〈0．05）。结论动物实验挂乐，聚桂醇在稀释至0．7％浓度以上时。依然能达到损伤血管．形成血栓，最终导敛注射段血管消失的效果。Objective To investigate the effects of different concentrations of lauromacrogol in travenous injection on the thrombosis and vascular walls through the animal experiment. Methods Thirty ear marginal veins of rabbits whose weight ranged from 2. 5 kg to 3.0 kg and whose sex was not limited were divided randomly into six groups= 1.0% lauromacrogol group. 0.9 % lauromacrogol group, 0.8% lauromacrogol group, 0. 7% lauromacrogol group, 0. 6% lauromacrogol group and normal saline group. The local veins and their side tissue were cut off for samples for HE staining and VEGF expression detected by immunohistochemistry at the first day, third day, fifth day and seventh day after injection. Results Visual observation and HE staining showed that 1.0 % lauromacrogol group. 0.9% lauromacrogol group, 0.8 % lauromacrogol group and 0.7% lauromacrogol group had thrombosis in veins after injection. 0.6 % lauromaerogol group and normal saline group did not have thrombosis in veins after injection. The score of VEGF expression showed that 1.0% lauromacrogol group, 0.9% lauromaerogol group, 0.8% lauromacrogol group and 0.7% lauromacrogol group did not have statislically significant differences between groups and different time point （P〉0. 05） and there were statistically significant differences between 0. 6% lauromacrogol group and other four groups （P〈 0. 05 ） in each time point. Conclusions From these animal experiments lauromacrogol eventually leading to the injected vein disappeared

关 键 词：聚桂醇 硬化剂注射 静脉血管 内皮生长因子 

分 类 号：R622[医药卫生—整形外科]