Direct C(sp^2)-H chlorination of ketene dithioacetals using FeCl_3 as the chloride source and PhI(OAc)_2 as an oxidant  

作　　者：MENG XianYu FANG ZhongXue BARRY Badru-Deen LIAO PeiQiu BI XiHe 

机构地区：[1]Department of Chemistry,Northeast Normal University

出　　处：《Chinese Science Bulletin》2012年第19期2361-2363,共3页

基　　金：supported by the National Natural Science Foundation of China (20902010 and 21172029);the Fundamental Research Funds for the Central Universities (10JCXK005)

摘　　要：The oxidant iodosobenzene diacetate was combined with the cheap,environment-friendly FeCl3 as a chloride source to produce an efficient chlorinating agent for α-chlorination of ketene dithioacetals through direct C(sp2)-H chlorination.Furthermore,the synthetic utility of α-chlorinated ketene dithioacetals was verified by the intermolecular cyclization with hydrazine hydrate,leading to the synthesis of pyrazoles,in which a 1,2-sulfur migration was involved.The oxidant iodosobenzene diacetate was combined with the cheap, environment-friendly FeC13 as a chloride source to produce an efficient chlorinating agent for a-chlorination of ketene dithioacetals through direct C（sp2）-H chlorination. Furthermore, the synthetic utility of a-chlorinated ketene dithioacetals was verified by the intermolecular cyclization with hydrazine hydrate, lead- ing to the synthesis of pyrazoles, in which a 1,2-sulfur migration was involved.

关 键 词：二硫缩烯酮 三氯化铁 氧化剂 SP2 酰基 OAC PHI 环境友好型 

分 类 号：O621.2[理学—有机化学]