阿司匹林耐受不良三联征的临床特点  

Analysis and research of clinical features of aspirin intolerance triad

作　　者：王长青[1] 李新平[1] 赵文敏[1] 王忠[1] 曾鸿斌[1] 张华[1] 刘立中[2] 

机构地区：[1]西双版纳州人民医院耳鼻咽喉科,云南西双版纳666100 [2]新疆医科大学第一临床医学院耳鼻咽喉科,乌鲁木齐830054

出　　处：《山东大学耳鼻喉眼学报》2012年第3期45-47,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的探讨阿司匹林耐受不良三联征(aspirin intolerance triad,AIT)的临床特点,以提高诊治及预防水平。方法采用回顾性研究的方法,对新疆医科大学一附院收治的35例AIT患者临床资料并结合文献进行分析。结果本组男13例(37%),女22例(63%),男女比例约0.59∶1;21～69岁,平均(36±16)岁。不耐受药物种类中:水杨酸类25例,占71%;丙酸类2例,占6%;吡唑酮类8例,占23%;灭酸类、昔康类、昔布类均无。临床类型中:鼻炎基础型11例,占32%;阿司匹林耐受不良基础型19例,占54%;哮喘基础型5例,占14%。本组25例行鼻窦CT检查显示鼻窦炎以多发或全组为主。本组23例行功能性内镜鼻窦手术获得临床治愈,术后鼻息肉行病检,水肿型13例,占57%,腺囊泡型6例,占26%,纤维型4例,占17%;12例予以抗炎、平喘治疗好转出院。结论 AIT患者症状较重,积极预防、早期诊断、合理治疗可减少AIT患者严重并发症的发生,提高生活质量。Objective To investigate clinical characteristics and improve the level of diagnosis, treatment and pre- vention in patients with aspirin intolerance triad. Methods A retrospective study of the clinical data and analysis of literature was performed on 35 cases of AIT （ aspirin intolerance triad）. Results There were 13 males （37 % ） and 22 females （63 % ） with a ratio of 0.59：1 （M：F）. The age ranged from 21 years to 69 years （average 36 ＋ 16 years）. In view of the type of drug intolerance, 25 cases were the salicylic acid-type, accounting for 71%, mainly to aspirin; 2 cases the propionic acid-type, accounting for 6%, mainly to naproxen; 8 cases the pyrazole ketones, accounted for 23%, mainly to analgin; and no anti-acid, oxicams, or coxibs. In clinical type： 11 cases were the rhinitis founda-tion, accounting for 32% ; 19 cases the asthma starts, accounting for 54% ; and 5 cases the asthma foundation, ac- counting for 14% （37%）. 25 cases had CT examination which revealed a regular sinus sinusitis or whole multiple group-oriented. 23 had FESS were routinely cured, pathological examination of 13 cases （57%） showed dropsy , 6 cases （26%） gland pouch soak, and 4 cases（ 17% ） textile fiber. The other 12 cases were discharged with improve- ment after anti-inflammatory and anti-asthmatic treatment. Conclusion Early prevention, diagnosis, and rational treatment are helpful in improving the diagnosis and treatment of AIT.

关 键 词：阿司匹林三联征 阿司匹林耐受不良 鼻息肉 支气管哮喘 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]