骨水泥对兔股骨头微循环影响的实验研究  

Experimental Study on Effect of Injected PMMA in Normal Rabbit Femoral Head Microcirculation

作　　者：杨云龙[1] 张卫平[1] 刘长安[1] 

机构地区：[1]中国人民解放军白求恩国际和平医院骨科,河北石家庄050082

出　　处：《解剖与临床》2012年第2期119-122,共4页Anatomy and Clinics

摘　　要：目的：探讨股骨头内甲基丙烯酸甲酯（骨水泥）注入对正常股骨头微循环影响。方法：选用纯种中国大白兔30只，左侧股骨头内注入骨水泥为实验组，右侧为穿刺对照组。分别于术后4周、8周、12周各取10只动物进行墨汁灌注及股骨头标本采集。显微镜下观察骨水泥注射后股骨头内骨水泥一骨组织学形态；每个标本切片取10个低倍视野，对微血管数计数。采用SPSS12．0软件做统计分析。结果：大体观察两组股骨头外形圆而光滑，关节软骨无剥脱及变性；实验组股骨颈断面可见骨水泥嵌入骨小梁之间。骨水泥注入后沿骨小梁间隙浸润，挤占骨小梁间隙内空间，骨水泥与正常骨小梁组织成为一种嵌合状态。实验组术后4周时位于骨小梁间隙内的微血管由于与骨水泥接触密切，数目明显减少，术后8周时开始逐渐恢复，术后12周时明显增多；对照组术后骨小梁间隙内微血管数目无明显变化。结论：骨水泥注入股骨头后由于化学及热烧伤作用，初期对股骨头内骨小梁表面造成了一定程度的损伤，导致微血管数减少，随着时间的延续，微血管数目恢复，股骨头的血液供应也得到了恢复。Objective：To investigate the influence of injected the polymethyl methacrylate plastics （hone cement） on the normal femur head microcirculation. Methods ：30 Chinese white purebred rabbits were selected and divided into experimental group（ bone cement was injected into the left femoral head） and puncture control group. The India ink perfusion and the sample collection of the femur head were respectively performed in 10 rabbits of each group in the fourth, eighth and twelfth week after operation. The bone cement -bone tissue form in the femur head was observed under the microscope after the injection of bone cement. Ten low power fields were taken from each sample and the microvessel count was collected. The statistical analysis was made through the SPSS 12.0 Software. Results：The outline form of femur head was round and smooth. There were no articular cartilage exfoliation and denaturalization. In experimental group, the bone cement inserted into the interspace among bone trabeculae could be seen in the cross - section of femur neck. The bone cement injected into the interspace began to soak in the space along the bone trabeculaes, occupy the space among the bone trabeculaes and formed the gomphosis state between the bone cement and bone tradeculaes, in experimental group, four weeks after the operation,the microvessel count among bone trabeculaes obviously decreased because the microvessel closely contacted with bone cement. Eight weeks after the operation, the microvessel count among the bone trabeculaes began to restore gradually. Twelve weeks after the operation, the microvessel count among the bone trabeculaes obviously increased. In control group, the microvessel count among the bone trabeculaes have no change after operation. Conclusions： Because of the chemical and thermal burn function, the bone cement inserted into the femur head can cause certain injury to the bone trabeculaes surface in the femur head at the beginning and result in the decrease of the microvessel count. With the process

关 键 词：骨水泥 股骨头 微血管 墨汁灌注 

分 类 号：R681.8[医药卫生—骨科学]