针刺对光老化大鼠皮肤组织中SOD、MDA、GSH-Px活性的影响  

The effect of acupuncture on the the activity of SOD,MDA and GSH-Px on photoaging rats

作　　者：张小卿[1] 陶冶[1] 田国伟[1] 吴景东[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《中国美容医学》2012年第7期1168-1170,共3页Chinese Journal of Aesthetic Medicine

基　　金：辽宁省教育厅科学研究项目(课题编号2008T122)

摘　　要：目的:研究针刺对UV照射引起的皮肤光老化大鼠皮肤组织中超氧化物歧化酶(SOD)、丙二醛(MDA)的含量及谷胱甘肽氧化酶(GSH-Px)活性的影响,探讨针刺对抗皮肤光老化的作用。方法:将大鼠随机分成4组,除正常组外,其余各组模拟日光中UV(UVA+UVB)照射,造成皮肤光老化模型。每次造模前,针刺组给予电针刺激,阳性对照组采用VE涂抹造模部位,15周后对比各组生化指标结果。结果:模型组与正常组比较大鼠皮肤组织中SOD、GSH-Px活性明显降低,MDA含量明显增加(P<0.05);针刺组与模型组比较SOD、GSH-Px活性增加,MDA含量明显降低(P<0.05),与VE组比较无统计学意义(P>0.05)。结论:针刺可对抗UV引起的皮肤光老化,其机理可能是通过增强皮肤中SOD、GSH-Px活性,降低MDA含量来改变皮肤的老化外观的。Objective To study the effect of acupuncture on the the activity of Superoxide Dismutase （SOD） and Glutathione Peroxidase （GSH-Px）as well as the content of Malon Diatdehyde （MDA） on cutaneous tissue of photoaging rats and to investigate the the mechanism of acupuncture on photoaging rats. Methods The rats were divided into 4 groups,except for the normal control group,the rats of other groups all accepted the artificial UV radiation （UVA＋UVB）. The rats of acupuncture group accepted Electro acupuncture,Vitamin E cream was used on rats back in positive control group,After 15 weeks,compare the results of biochemical indicator of each groups. Results Comparing with the normal control group,the activity of SOD and GSH-Px in model group were Significantly decreased,the content of MDA was Significantly increased （P〈0.05）. Comparing with the model group,the SOD and GSH-Px in model group were Significantly increased,the content of MDA was Significantly decreased （P〈0.05） and no statistically significant to compare with the VEgroup. Conclusion acupuncture may against the photoaging and alter the appearance of photoaging skin by increasing the activity of SOD and GSH-Pxand,decreasing the content of MDA on cutaneous tissue of photoaging rats.

关 键 词：针刺 光老化 超氧化物歧化酶 丙二醛 谷胱甘肽氧化酶 

分 类 号：Q591.3[生物学—生物化学]