糠酸莫米松乳膏联合维A酸乳膏治疗黄褐斑疗效分析  

Clinical efficacy and safety of momestasone furoate ointment combining with tretinoin cream for chloasma

作　　者：张合立[1] 籍红[1] 王文格[1] 刘晓涛[1] 张勇枚[1] 郑玲玲[1] 

机构地区：[1]首都医科大学潞河教学医院皮肤性病科,北京101100

出　　处：《中国美容医学》2012年第7期1176-1178,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨糠酸莫米松乳膏联合维A酸乳膏治疗黄褐斑的疗效和安全性。方法:76例黄褐斑患者被随机分为对照组(47例)和治疗组(39例),对照组每晚涂抹0.1%维A酸乳膏,治疗组每晚将0.1%糠酸莫米松乳膏和0.1%维A酸乳膏按1:l均匀混合并涂抹于患处,观察时间12周。结果:对照组与治疗组总有效率分别为64.86%和84.61%,组间差异显著(P<0.05);两组不良反应发生率分别为59.46%和17.95%,组间差异显著(P<0.01)。结论:糠酸莫米松乳膏联合维A酸乳膏治疗黄褐斑的效果明显比维A酸单用好,并且两者联合应用显著降低了维A酸的副作用。Objective To observe the clinical efficacy and safety of 0.1% momestasone furoate ointment combining with 0.1% tretinoin cream for Chloasma. Methods 76 cases of chloasma were randomly divided into control group（37 cases） and treatment group （39 cases）.Patients in control group were only administered with 0.1% tretinoin cream,while patients in treatment group were administered with the mixture of 0.1% momestasone furoate ointment and 0.1% tretinoin cream in 1to 1 proportion every night.The course of treatment was 12 weeks.The rates of effectiveness and adverse reactions in two groups were compared. Results The rates of effectiveness in control group and treatment group were 64.86%and 84.61%.There was significant difference between two groups （P〈0.05）.The incidence of adverse reactions in two groups were 59.46%and 17.95%.There was significant difference between two groups （P〈0.01）. Conclusion Momestasone furoate ointment combining with tretinoin cream is effective and safe for patients with chloasma.

关 键 词：黄褐斑 糠酸莫米松 维A酸 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]