ACEI联合ARB治疗早期特发性膜性肾病疗效观察  

Effect of Benazepril with Valsartan on Idiopathic Membranous Nephropathy in Early Stage

作　　者：张璟[1] 刘伟[1] 施杰[1] 端靓靓[1] 苏安生[1] 韩久怀[1] 

机构地区：[1]安徽省安庆市立医院肾内科,246000

出　　处：《中华全科医学》2012年第7期1059-1060,1112,共3页Chinese Journal of General Practice

摘　　要：目的探讨贝那普利联合缬沙坦对早期特发性膜性肾病的临床疗效。方法选择早期特发性膜性肾病患者62例,采用前瞻、随机、对照研究,分为对照组(Control)、缬沙坦组(valsartan)、贝那普利组(Benazepril)、贝那普利联合缬沙坦组(Benazepril+valsartan)。Control组仅给予限制蛋白饮食,血脂升高者给予降脂等一般治疗;缬沙坦组组在对照组基础上给予valsartan 80 mg/d,如无副作用及低血压增加剂量至160 mg/d;Benazepril组在对照组基础上给予Benaze-pril 10 mg/d,如无副作用及低血压增加剂量至20 mg/d;Benazepril+valsartan组在valsartan组基础上合用Benazepril 10～20 mg/d,1次/d;以上各组疗程共8周。结果与治疗前比较,除对照组外,valsartan组、Benazepril组与Benazepril+val-sartan组24小时尿白蛋白量均有下降(P<0.01);与其它组比较,Benazepril+valsartan组作用更显著(P<0.05)。结论贝那普利联合缬沙坦可以快速降低早期特发性膜性肾病的尿蛋白排泄量,提升白蛋白水平,促使病情缓解。Objective To explore the efficiency of Benazepril combined with valsartan in treatment of idiopathic membranous nephropathy（IMN） in the early stage.Methods Sixty two cases of IMN were randomly divided into control group,valsartan group,Benazepril group and Benazepril with valsartan group by a prospective randomized controlled trial.The patients in all groups received a low-protein diet and lipid-lowering therapy.The valsartan group was treated with valsartan 80 mg/d and should be increased to 160 mg/d if there was no hypotension and other side effects;the Benazepril group as treated with Benazepril 10 mg/d and should be increased to 20 mg/d if there was no hypotension and other side effects;the combination group received Benazepril 10-20 mg/d every day based on the valsartan group.The courses of all groups were 8 weeks.Results The 24-hour urinary albumin excretion has decreased as compared to the levels before treatment except the control group（P0.01）,and the difference was more significant between the combination group and other groups（P0.05）.Conclusion Benazepril with valsartan can rapidly decrease the 24-hour urinary albumin excretion and promote the level of serum albumin in early idiopathic membranous nephropathy.

关 键 词：早期 特发性膜性肾病 缬沙坦 贝那普利 联合 

分 类 号：R692[医药卫生—泌尿科学]