丙种球蛋白佐治儿童重症支原体肺炎疗效分析  

Effect of Immunoglobulin for Childhood Severe Mycoplasm Pneumonia

作　　者：郑刚[1] 邓衍圣[1] 王俊男[1] 

机构地区：[1]安徽省宿州市立医院儿科,234000

出　　处：《中华全科医学》2012年第7期1072-1073,共2页Chinese Journal of General Practice

摘　　要：目的观察静脉注射用人免疫球蛋白佐治重症肺炎支原体肺炎的临床疗效及不良反应。方法选择2010年10月-2011年11月重症肺炎支原体肺炎113例,随机分为治疗组和对照组,治疗组56例和对照组57例,两组患儿均先后给予红霉素、阿奇霉素序贯治疗及对症治疗,疗程2周左右,治疗组在以上治疗基础上加静脉注射用人免疫球蛋白400 mg/(kg.d),连用3 d。结果治疗组发热、咳嗽、干啰音、湿啰音消失时间分别为(2.1±1.3)d、(4.2±1.2)d、(2.5±1.2)d、(3.6±1.1)d,对照组分别为(3.3±1.0)d、(5.6±2.3)d、(4.3±2.5)d、(5.4±1.8)d,两组比较差异有统计学意义(P<0.01)。结论静脉注射用人免疫球蛋白佐治重症肺炎支原体肺炎,临床疗效确切,无不良反应。Objective To observe the clinical curative effect and safety of human immunoglobulin for intravenous injection in treating childhood severe mycoplasm pneumonia.Methods One hundred and thirty three children with severe mycoplasm pneumonia in clinic and wards of this hospital from October 2010 to November 2011 were randomly divided into treatment group（n=56） and control group（n=57）.All the patients were administered with erythromycin,azithromycin and symptomatic treatment for two weeks.The treatment group also received human immunoglobulin for intravenous injection 400 mg/（kg·d） for 3 days compared to the control group.Results The symptom-free period of fever,cough,wheeze and wet rales in the treatment group were（2.1±1.3）d,（4.2±1.2）d,（2.5±1.2）d and（3.6±1.1）d,respectively;and in the control group（3.3±1.0）d,（5.6±2.3）d,（4.3±2.5）d and（5.4±1.8）d,respectively.The difference between the two group was statistically significant（P0.01）.Conclusion Human immunoglobulin for intravenous injection has a greater efficacy and fewer side effects on children with mycoplasm pneumonia.

关 键 词：丙种球蛋白 肺炎支原体 肺炎 

分 类 号：R725.6[医药卫生—儿科]