柚皮素增强乙肝疫苗免疫效果的探讨  

Research for the naringenin to strengthen the immune effects of hepatitis B vaccine

作　　者：赵粤萍[1] 刘瑞敏[1] 朱诗白[1] 马远方[1] 

机构地区：[1]河南大学细胞与分子免疫学重点实验室,河南开封475004

出　　处：《河南大学学报（医学版）》2012年第2期119-120,共2页Journal of Henan University:Medical Science

基　　金：河南省重点科技攻关资助项目(0224630174)

摘　　要：目的探讨柚皮素作为佐剂增强HBV疫苗的体液免疫效果。方法用柚皮素作为免疫佐剂免疫Balb/c小鼠,以佐剂铝盐作为阳性对照,在免疫3次后取小鼠血清做ELISA检测HBsAb滴度,比较各组的免疫效果。结果与无佐剂组小鼠对比,柚皮素和铝盐作为佐剂均可有效地引起小鼠对HBsAg的体液免疫应答。结论柚皮素可以增强乙肝疫苗的免疫效果,和铝盐相比没有统计学意义。Objective To study the naringenin as adjuvant to enhance the immune effects of hepatitis B vaccine. Methods We used naringenin as adjuvant to immune Balb/c mice and used the aluminium salt as the positive control. We took the serum of the mice to do ELISA to test the concentration of HBsAb after 7 days that we injected the hepatitis B vaccine to the mice three times. Results The naringenin and aluminium salt as adjuvants could effectively cause mice to HBsAg humoral immune response compared with that of the non-adjuvants groups. Conclusion The naringenin could enhance the immune effects of hepatitis B vaccine. There was no statistically significant compared to the aluminum salt.

关 键 词：柚皮素 佐剂 免疫效果 

分 类 号：R392.11[医药卫生—免疫学]