禽异嗜性粒细胞与机体免疫研究进展  

Progress on Avian Heterophils and Immune Response

作　　者：秦倩倩[1] 白换力[1] 张立艳[1] 董海兵[1] 褚秀玲[2] 付本懂[1] 韦旭斌[1] 申海清[1] 

机构地区：[1]吉林大学畜牧兽医学院,吉林长春130062 [2]聊城大学农学院,山东聊城252000

出　　处：《动物医学进展》2012年第6期107-110,共4页Progress In Veterinary Medicine

基　　金："十一五"国家科技支撑计划(2008BADB4B04-4);北京农学院兽医学(中医药)北京市重点实验室开放课题(TCVM-201104);中国农业科学院兰州畜牧与兽药研究所农业部兽用药物创制重点实验室甘肃省新兽药工程重点实验室开放课题(SYSKF2011KT05)

摘　　要：禽异嗜性粒细胞是存在于禽类血液中的一种主要的颗粒性白细胞,类似于哺乳动物的中性粒细胞,是禽类抵御外界微生物病原体入侵的一道重要防线,也是机体非特异性免疫系统中的重要成员和主要调节者。近年来,对于该细胞在机体急性炎症反应和吞噬杀伤作用中的研究已经深入到了基因和蛋白水平,为从禽类异嗜性粒细胞方面入手治疗禽类疾病,提供了理论依据和研究方向。论文从异嗜性粒细胞与中性粒细胞在形态结构,急性炎症反应和吞噬杀伤病原体作用中的区别,以及近年来该细胞的其他研究热点等方面综述了禽类异嗜性粒细胞的研究进展。Avian heterophils is a predominate granulated leukocyte in the avian blood. Similar to the neutro- phils in mammalian, avian heterophils is an important line of defense of poultry against external invasion of microbial pathogens, as well as an important member and regulator of the innate immune system. Although they play the same important immune role, they have different performance in the acute inflammatory response and the process of phagocytic killing effect. In recent years, the research on this cells has deep into the mRNA and protein levels, these research achievements provide adequate theoretical basis and new research direction to prevent and treat avian diseases in heterophil aspect. There{ore, the differentances between heterophils and neutrophils in morphological structure, acute inflammatory response and phagocytic killing effect aspects were reviewed.

关 键 词：禽 异嗜性粒细胞 急性炎症反应 吞噬杀伤 

分 类 号：S854.53[农业科学—临床兽医学]