壳聚糖衍生物纳米粒子的制备及对体内放射性锶的促排作用  

Preparation and Its Decorporation of Radiostrontium of Chitosan Derivative Nanoparticles in Vivo

作　　者：翟小刚[1] 许玉杰[1] 刘敏[1] 舒洪灶[1] 杨百霞[1] 

机构地区：[1]苏州大学医学部放射医学与防护学院基础核医学教研室,江苏苏州215123

出　　处：《中国辐射卫生》2012年第2期129-131,共3页Chinese Journal of Radiological Health

基　　金：江苏省高校优势学科建设工程(PAPD);国家自然科学基金(30970873)支持

摘　　要：目的制备壳聚糖-乙二胺四乙酸(CTS-EDTA)纳米粒,通过动物实验观察壳聚糖-乙二胺四乙酸纳米粒(CEC-Nano)对放射性锶的促排效果尤其是预防性给药的促排效果。方法通过N-酰化反应连接壳聚糖与乙二胺四乙酸纳,并将反应产物与TPP利用离子凝胶法制成纳米粒。通过染毒前与染毒后给药,比较其治疗性与预防性促排效果。结果 CTS-EDTA纳米粒通过透射电镜观察显示可得到粒度较为均一的球形纳米粒子。体内实验表明,小鼠骨头尤其是颅骨的放射性锶含量在预防给药治疗组比对照组和即刻给药治疗组明显低(P<0.05),小鼠体内整体放射性锶残留量也比其他组明显低(P<0.05)。结论 CEC-Nano对体内放射性锶具有良好的促排效果尤其是预防性给药治疗促排效果更好。Objective To prepare CTS - EDTA nanoparticles and evaluate their decorporation effect on 89 Sr in mice, especially preventive effects. Methods CTS - EDTA was synthesized by N - acylation reaction and its nanoparticles （ CEC - Nano） was prepared by cross -linking CTS -EDTA with sodium tripolyphosphate （TPP）. The decorporation effects on S9Sr have been compared between the groups of the post - contamination and pre - contamination through administering the CEC - Nano chelater. Results CEC - Nano was confirmed to be spherical with uniform size by TEM. Radioactivity of skull as well as body residue in the pre - contamination group was lower than that in control and post - contamination groups. Conclusion CEC- Nano has good effect to the decorporation on 89Sr, especially when administered precontamination of radiostrontium.

关 键 词：放射性锶 壳聚糖-乙二胺四乙酸(CTS-EDTA) 纳米粒子 促排 

分 类 号：R147[医药卫生—公共卫生与预防医学]