真菌对唑类药物耐药机制研究进展  

Research advance of fungal resistance mechanism against azoles

作　　者：芦现杰[1] 郑玉果[1] 周斌[1] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200040

出　　处：《世界临床药物》2012年第6期363-368,共6页World Clinical Drug

摘　　要：临床唑类药物耐药率逐渐升高,严重影响抗真菌感染的治疗效果。本文从分子水平分析常见致病菌的相关耐药基因,综述相关耐药机制的研究进展,旨在为合理利用唑类药物和新型抗真菌药物的研发提供理论依据。The fungal resistance rate against azoles is increasing gradually, which affects clinical treatment efficacy seriously. Based on the analysis of resistant pathogen gene and the research of fungal resistance mechanism, this article provides a proposal for rational use of azoles and other new antifungal drugs.

关 键 词：真菌 唑类药物 耐药机制 

分 类 号：R978.5[医药卫生—药品]