可溶性转铁蛋白受体在缺铁性贫血诊断中的临床应用价值  被引量:13

Clinical application significance of serum soluble transferrin receptor in diagnosis of iron deficiency anemia

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作  者:柏晓松[1] 金立钢[1] 刘云[1] 

机构地区:[1]上海市杨浦区市东医院检验科,上海200438

出  处:《检验医学》2012年第6期454-456,共3页Laboratory Medicine

摘  要:目的探讨血清可溶性转铁蛋白受体(sTfR)在缺铁性贫血(IDA)诊断中的临床应用价值。方法选择正常对照组和IDA患者组各58例,同等条件下对2组sTfR、血清铁(Fe)、总铁结合力(TIBC)、转铁蛋白饱和度(TS)、转铁蛋白(Tf)、血清铁蛋白(SF)、血红蛋白(Hb)、平均红细胞容积(MCV)、平均红细胞血红蛋白量(MCH)、平均红细胞血红蛋白浓度(MCHC)、红细胞体积分布宽度(RDW)等指标进行定量检测,并分别行t检验和ROC曲线分析。结果 IDA组血清sTfR浓度为(46.40±9.43)nmol/L,正常对照组的sTfR浓度为(15.45±2.95)nmol/L,与对照组比较,IDA组血清sTfR明显升高,差异具有统计学意义(P<0.01)。用于IDA诊断时,sTfR的ROC曲线下面积达0.971(P<0.01)。结论血清sTfR浓度可较准确反映铁贮存状况,对IDA的诊断具有一定的临床实用价值。Objective To investigate the clinical application significance of serum soluble transferrin receptor (sTiR) in diagnosis of iron deficiency anemia (IDA). Methods A total of 58 controls and 58 patients with IDA were enrolled in the study. Iron metabolism related indices such as sTiR, serum iron(Fe) , total iron binding capacity (TIBC) , transferrin saturation (TS) , transferrin (TF) , serum feiTitin (SF) , hemoglobin (Hb) , mean corpuscular volume (MCV) , mean corpuscular hemoglobin (MCH) , mean corpuscular hemoglobin concentration (MCHC) and red blood cell volume distribution width ( RDW ) were detected quantitatively. The data were analyzed by t test between groups and receiver operating characteristic (ROC) curve. Results The levels of sTiR were (46.40± 9.43) nmol/L in IDA group and ( 15.45±2.95 ) nmoL/L in control group. There were statistical significances between the sTiR levels of IDA and control groups (P 〈 0.01 ). The area under the ROC curve of sTfR was 0. 971 ( P 〈 0.01 ). Conclusions Serum sTiR can reflect iron storage in body correctly. The sTiR has a clinical application significance in the diagnosis of IDA.

关 键 词:可溶性转铁蛋白受体 缺铁性贫血 临床应用价值 

分 类 号:R446.1[医药卫生—诊断学]

 

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