慢性肾炎病人外周动脉病的相关危险因素分析  

Related risk factors for peripheral arterial disease in patients with chronic nephritis

作　　者：程艳[1] 

机构地区：[1]郑州市第三人民医院血液净化中心,河南郑州450000

出　　处：《青岛医药卫生》2012年第3期187-188,共2页Qingdao Medical Journal

摘　　要：目的分析并探讨慢性肾炎病人下肢外周动脉疾病的发生状况及其危险因素。方法测量全部病人的踝臂指数,根据踝臂指数将病人分成外周动脉疾病组与非外周动脉疾病组,比较两组的心电图、血生化以及24h尿蛋白定量。结果全部149例慢性肾炎病人中发生外周动脉疾病者26例,占17.4%。两组病人在心肌缺血、脑卒中病史、心肌梗死史以及间歇性跛行的发生率方面比较差异显著(P<0.01),均具统计学意义。经多元逐步回归分析结果显示,血肌酐、收缩压以及24h尿蛋白定量与慢性肾炎病人踝臂指数关系最为密切。结论慢性肾炎病人易发生外周动脉疾病,有外周动脉疾病的慢性肾炎病人心脑血管病变的发生率增高;踝臂指数测量诊断外周动脉疾病能间接反映出慢性肾炎病人发生心脑血管疾病的危险性。Objective To analyze and investigate risk factors of chronic nephritis patients with peripheral arterial disease. Methods All patients ankle-brachial index were measured, and patients were divided into the ankle-brachial index of peripheral arterial disease group and the non-peripheral arterial disease group. ECG, blood biochemistry, and 24h urinary protein excre- tion were compared between the two groups. Results In 149 cases chronic nephritis patients, pe- ripheral arterial disease occurred in 26 cases, accounting for 17. 4%. The incidence of myocardial ischemia, stroke history, history of myocardial infarction and intermittent claudication in the two groups was significantly different（P〈0.01）. By stepwise regression analysis, it showed that ser- um ereatinine, systolic blood pressure and 24h urinary protein excretion are closely related to an- kle brachial index of chronic nephritis patients. Conclusion Chronic nephritis patients prone to peripheral arterial disease. Cerebral vascular disease incidence increased in peripheral arterial dis- ease patients with chronic nephritis; ankle-brachial index measurement of the diagnosis of periph- eral arterial disease indirectly reflects the cardiovascular and cerebrovaseular diseases risk in chro- nic nephritis patients.

关 键 词：慢性肾炎 周围动脉病 踝臂指数 危险因素 

分 类 号：R692.3[医药卫生—泌尿科学]