小剂量红霉素治疗支原体肺炎临床评价  

Evaluation of the Clinical Efficacy of Low Dose Erythromycin in Treating Mycoplasma Pneumonia

作　　者：张丽萍[1] 刘继红[2] 李淑琴[3] 

机构地区：[1]武警山西总队医院儿科,太原030006 [2]武警山西总队医院检验科,太原030006 [3]武警山西总队医院防染科,太原030006

出　　处：《临床误诊误治》2012年第6期71-73,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的观察小剂量红霉素治疗肺炎支原体肺炎的临床效果。方法将我科收治的肺炎支原体肺炎随机分成小剂量组和常规剂量组,每天分别予小剂量(10 mg/kg)和常规剂量(30 mg/kg)注射用乳糖酸红霉素治疗,10 d为一疗程,对两组的临床表现、医技检查结果及不良反应进行对比分析。结果两组发热消退时间(t=1.0642,P>0.05)、咳嗽缓解时间(t=0.8451,P>0.05)、啰音消失时间(t=0.6721,P>0.05)、血白细胞恢复时间(t=0.8723,P>0.05)及治疗10 d后X线胸片阴影消散率(χ2=2.085,P>0.05)等方面比较差异无统计学意义;两组穿刺局部疼痛率比较差异无统计学意义(χ2=2.040,P>0.05),但恶心(χ2=33.38,P<0.05)、呕吐(χ2=52.23,P<0.05)、食欲缺乏(χ2=54.37,P<0.05)等胃肠道症状比较差异均有统计学意义;2周后复查丙氨酸转氨酶差异也有统计学意义(χ2=78.13,P<0.05)。结论小剂量红霉素治疗肺炎支原体肺炎效果肯定,不良反应少。Objective To observe the clinical efficacy of low dose erythromycin in treating mycoplasma pneumonia. Methods Patients with mycoplasma pneumonia in our hospital were randomly divided into two groups （low-dose group and control group）. Low-dose group was administered with intravenous drip of low dose erythromycin lactobionate （10 mg/kg） once a day and control group was administered with intravenous drip of routine dose erythromyein lactobionate （30 mg/kg） once a day. One course of treatment was 10 d. The clinical efficacy, iatrical examinations and adverse reaction were compared after treatment. Results There was no statistical significance in regression time of fever （ t = 1. 0642, P 〉 0.05 ） , coughing released time （t =0. 8451, P 〉0.05）, rales extinction time （t =0. 6721, P 〉0. 05）, leucocyte in blood coincidnece time （t =0. 8723, P 〉 0. 05 ）, shadow dispersion rate by X-ray 10 days after treatment （χ2 = 2. 085, P 〉 0. 05） ; The differences for local pain by paracentesis of the two groups showed no significant differences （ χ2 = 2. 040, P 〉 0.05 ） , the incidence rates of gastrointestinal symptoms such as nausea （χ2 =33.38, P〈0.05）, vomiting （χ2 =52.23, P〈0.05） and anorexia （χ2 =54.37, P〈0.05） showed significant differences ; The differences of ALT in the two groups after two weeks of review showed significant differences （χ2 = 78.13, P 〈 0. 05）. Conclusion Low dose erythromycin is effective in the treatment of mycoplasma pneumonia with fewer adverse reactions.

关 键 词：红霉素 肺炎 支原体 小剂量 常规剂量 

分 类 号：R725.6[医药卫生—儿科]