脑星形细胞瘤磁敏感效应级别与1H-MR波谱相对定量的相关性探讨  

Correlation investigate between grade of intratumoral susceptibility signals and relative quantitative of 1H-MRS in patients with brain astrocytic tumours

作　　者：林祺[1] 张强[1] 陈东平[1] 许凯华[1] 陈金银[1] 

机构地区：[1]福建医科大学附属龙岩市第一医院放射科,龙岩364000

出　　处：《磁共振成像》2012年第3期174-178,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：福建省医学创新课题基金(2011-CXB-28)资助

摘　　要：目的探讨脑星形细胞瘤高分辨率磁敏感加权像(SWI)的瘤内磁敏感效应(ITSS)级别与多体素氢质子MR波谱(1H-MRS)相对定量的相关性,以评估对脑星形细胞瘤分级诊断的价值。方法搜集经病理证实的33例脑星形细胞瘤相关资料,根据33例SWI表现确定ITSS不同级别。多体素1H-MRS分别计算肿瘤实质区的胆碱(Cho)/肌酸(Cr),Cho/乙酰天冬氨酸(NAA)相对定量,并与ITSS分级进行相关性分析。结果高级别星形细胞瘤ITSS级别高于低级别星形细胞瘤(P<0.01)。高级别星形细胞瘤Cho/Cr、Cho/NAA相对定量比值均高于低级别星形细胞瘤(P<0.01)。ITSS级别越高Cho/Cr、Cho/NAA相对定量比值也越大,呈正相关性(r=0.763,r=0.741,P<0.01)。结论脑星形细胞瘤ITSS级别与1H-MRS相对定量有较强的正相关性,ITSS级别可作为脑星形细胞瘤的分级诊断指标。Objective： To investigate the correlation between the grade of intratumoral susceptibility signals （ITSS） in high-resolution susceptibility-weighted imaging（SWI） and relative quantitative of multi-voxel ^1H-MRS, and estimate its value on the grade of brain astrocytic tumours. Materials and Methods： The data of 33 patients with brain astrocytic tumours confirmed by postoperative pathologic were collected. Multi-voxel ^1H-MRS calculates respectively the relative quantitative of Choline （Cho）/Creotine （Cr）, Cho/N-acetylaspartate （NAA）, and analyze with grade of ITSS correlation. Results： The high grade astrocytic turnouts of ITSS classification was obviously higher than the low grade gliomas （P〈0.01）. The high grade astrocytic turnouts of Cho/Cr, Cho/NAA relative quantitative ratio was obviously higher than the low grade astrocytic turnouts （P〈0.01）. The higher the grade of ITSS was, the bigger the Cho/ Cr, Cho/NAA of relative quantitative ratio was, which showed positive correlation （r=0.763, r=0.741, P〈0.01）. Conclusion： There is better positive correlation between grade of ITSS and relative quantitative of ^1H-MRS in patients with brain astrocytic tumours. The grade of ITSS in brain astrocytic tumours can be used as classification diagnostic index.

关 键 词：脑 星形细胞瘤 磁敏感加权像 磁共振波谱学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.264[医药卫生—诊断学]