慢性乙型肝炎患者血清补体C3和C4检测的临床意义再探讨  

Further study on clinical significance of complement 3 and complement 4 in patients with chronic hepatitis B

作　　者：吕邦泰[1] 高国生[1] 冯家飞[1] 徐晓珍[1] 祝成亮[2] 

机构地区：[1]浙江省宁波市第二医院检验科,浙江宁波315010 [2]武汉大学人民医院检验科,武汉430060

出　　处：《中国卫生检验杂志》2012年第6期1327-1328,共2页Chinese Journal of Health Laboratory Technology

基　　金：国家自然科学基金(81101485);吴阶平医学基金会肝病实验诊断研究基金(LDWMF-SY-2011C004);宁波市自然科学基金(2010A610056)

摘　　要：目的:再次探讨慢性乙型肝炎患者血清补体C3和C4检测的临床意义。方法:通过德灵BNⅡ特种蛋白仪检测慢性乙型肝炎患者和健康对照者C3和C4血清学水平,分析C3和C4在不同病情及不同HBV-DNA拷贝数慢性乙型肝炎患者中表达水平的差异。结果:慢性乙型肝炎患者的血清补体C3和C4水平较正常对照组显著降低(P<0.05),特别是补体C3在病情较重和HBV-DNA复制活跃时下降明显。结论:慢性乙型肝炎患者补体C3和C4血清学水平反应病情轻重,且受体内HBV-DNA负向调节。Objective：To further study the clinical significance of complement 3（C3） and complement 4（C4）in patients with chronic hepatitis B.Methods：Serum C3 and C4 levels in patients with chronic hepatitis B and healthy individuals were measured by Behring nephelometer systems（BNⅡ）,the difference of serum C3 and C4 among chronic hepatitis B patients at different stages and different HBV-DNA load were analyzed.Results：The serum C3 and C4 levels were lower in patients with chronic hepatitis B as compared to healthy individuals（P0.05）,especially the serum C3 level significantly decreased in patients with severe chronic hepatitis B and high HBV-DNA load.Conclusion：The serum complement level is associated with the disease progression in chronic hepatitis B patients,and it can be negatively regulated by HBV-DNA.

关 键 词：乙型肝炎病毒 DNA 补体C3 补体C4 

分 类 号：R512.62[医药卫生—内科学]