肾移植患者促红细胞生成素监测的临床意义  

A study of inherent erythropoietin (EPO) before and after renal transplantation and its correlation to allograft function

作　　者：马麟麟[1] 石峰[2] 吴国荃[1] 汤勇[2] 张玉海[1] 

机构地区：[1]首都医科大学附属北京友谊医院泌尿科,北京100050 [2]空军总医院

出　　处：《中华泌尿外科杂志》2000年第2期90-91,共2页Chinese Journal of Urology

摘　　要：目的　探讨肾移植术后内源性促红细胞生成素（ＥＰＯ） 的动态变化与康复的关系。　方法　分别测定血透析和肾移植病例３２ 例。将移植病人按术前是否接受ＥＰＯ 治疗，分为ＥＰＯ 治疗组和非治疗组。动态观察手术前后ＥＰＯ变化过程。比较治疗和非治疗组的差异与血象变化。　结果　两组各观察点ＥＰＯ 实测值差异无显著性。ＥＰＯ 治疗组术后可见两次ＥＰＯ 升高高峰，分别为３２ｍＩＵ／ｍｌ 和２１ｍＩＵ／ｍｌ。贫血的改善不受ＥＰＯ 变化的影响，呈稳定上升趋势，第２１ 天两组血红蛋白平均达到９０ｇ／Ｌ，平均术后８ 天肾功能恢复正常。肾功能延迟恢复病例，欠缺二次ＥＰＯ 水平升高过程。　结论　肾移植术后监测ＥＰＯ水平，有助于预测和判断移植肾功能的康复和发生移植术后红细胞增多症（ＰＴＥ）的可能性。Objective To study the inherent erythropoietin (EPO) before and after renal transplantation and to investigate its correlation to allograft function. Methods In 55 cases of chronic renal failure underwent hemodialysis or renal transplantation,the EPO level has been followed up and its correlation with anemia and the allograft function was investigated. Results There was no significant differrence of EPO level between the hemodialysis and the renal transplantation group and the inherent EPO level has nothing to do with the correction of anemia.The allograft function usually recovered 8 days after transplantation and peripheral blood hemoglobin rose smoothly.In exogenous EPO treated patients,2 peaks of EPO level were observed after renal transplantation.If delayed recovery of the allograft function occurred,the second peak of EPO was dismissed. Conclusions Checking up of the inherent EPO level would be of help in estimating the allograft function after renal transplantation and in forecasting the possible occurrecnce of post transplantation erythrocytosis.

关 键 词：肾移植 促红细胞生长素 预后 

分 类 号：R699.2[医药卫生—泌尿科学]