小青龙汤药物血清对致敏大鼠腹腔肥大细胞脱颗粒以及组织胺释放的影响  

Effect of Xiaoqinglong Decoction Drug Serum on Degranulation and Histamine Releasing of Peritoneal Mastocyte in Sensitized Rats

作　　者：李仪奎[1] 吴健宇 吴晓芬 符胜光[1] 

机构地区：[1]上海中医药大学中药药理毒理研究中心,上海200032

出　　处：《中国中西医结合杂志》2000年第1期40-42,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金!(No .39630 360 )

摘　　要：目的 :研究小青龙汤抗过敏作用的机理。方法 :分别用形态法和荧光法观察了小青龙汤药物血清冻干粉对致敏大鼠腹腔肥大细胞 (PMC)脱颗粒和组织胺释放的影响。结果 :给药 15min、给药 2h后制备的药物血清冻干粉对PMC脱颗粒和组织胺释放有明显的抑制作用 ,且二者的时效关系基本一致。结论 :小青龙汤抗过敏作用与抑制PMC释放过敏介质———组织胺有关。Objective: To study the mechanism of anti allergic effect of Xiaoqinglong Decoction (XQLD). Methods: The influence of XQLD drug serum frozen powder on degranulation and histamine releasing of peritoneal mastocyte in sensitized rats was examined by morphologic and fluorimetric method. Results: The drug serum prepared by serum obtained 2 hours after medication for 15 min has obvious inhibitory effect on degranulation and histamine releasing of peritoneal mastocyte which showed a basically unified time effect relationship. Conclusion: The anti allergic effect of XQLD is related with the allergic medium (histamine) inhibition of releasing of peritoneal mastocyte.

关 键 词：小青龙汤 血清冻干粉 腹腔肥大细胞 组织腔释放 

分 类 号：R289.5[医药卫生—方剂学]