肾康注射液与苯那普利对肾小球系膜基质作用的对比研究  

Contrast Study on Effect of Shenkang Injection and Benazepril on Human Glomerular Mesangial Extracellular Matrix

作　　者：郭立中[1] 刘玉宁[2] 毛炜[3] 叶传蕙[2] 顾云[1] 周姗姗[4] 

机构地区：[1]南京中医药大学博士后流动站,南京210029 [2]成都中医药大学 [3]广东省中医院 [4]武警南京医院

出　　处：《中国中西医结合杂志》2000年第1期50-52,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局资助! (No.92DO89)

摘　　要：目的 :探讨肾康注射液与苯那普利对人肾小球系膜细胞外基质 (ECM )不同成分的抑制作用强度。方法 :采用体外培养的人肾小球系膜细胞技术 ,观察具有降逆泄浊、益气活血功效的中药肾康注射液及苯那普利对ECM不同成分的影响。结果 :肾康注射液具有抑制ECM成分中纤维连接蛋白 (FN)、层粘连蛋白 (LN)和Ⅳ型胶原 (ColⅣ )的作用 ,该抑制作用具有一定的量效关系。苯那普利对ECM中FN、ColⅣ也有一定的抑制作用 ,但不及肾康注射液作用明显。结论 :肾康注射液对ECM的抑制作用优于苯那普利。Objective: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM). Methods: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro. Results: SKI could inhibit the fibronetin, laminin, and type Ⅳ collagen of ECM, and the action was dose dependent. Benazepril could also inhibit the fibronetin and type Ⅳ collagen of ECM but was weaker in intensity. Conclusion: The effect of SKI was superior to Benazepril in inhibiting ECM.

关 键 词：肾康注射液 苯那普利 细胞外基质 肾小球系膜 

分 类 号：R965[医药卫生—药理学]