子宫内膜息肉中雌、孕激素受体的表达及临床意义  

Expression and significance of estrogen receptor,progesterone receptor in endometrial polyps

作　　者：佘远萍[1] 陈正勤[1] 杨冰[1] 李丽军[1] 张逢春[1] 黄玉梅[1] 

机构地区：[1]桂林医学院附属医院妇产科,广西桂林541001

出　　处：《华夏医学》2012年第2期142-144,共3页Acta Medicinae Sinica

基　　金：广西壮族自治区卫生厅计划课题资助(Z2009026)

摘　　要：目的:检测子宫内膜息肉雌激素受体(ER)、孕激素受体(PR)的表达,探讨其在子宫内膜息肉的发生机制。方法:前瞻性研究子宫内膜息肉患者40例,全部患者均接受宫腔镜下子宫内膜息肉切除术,切除子宫内膜息肉及周围正常内膜组织,采用免疫组化方法测定息肉组织和周围正常内膜组织中ER、PR的表达水平。结果:ER在息肉组的表达高于内膜组,PR在息肉组的表达低于内膜组,差异有统计学意义(P<0.05)。结论:子宫内膜息肉中ER、PR的异常表达可能参与了子宫内膜息肉形成的病理过程。Objective. To detect the expressions of estrogen receptor （ER） and progesterone receptor （PR） in endometrial polyps and discuss their pathogenesis mechanism in endometrial polyps. Methods. Prospective study was performed on 40 patients. All the patients had received the transcervical resection of polyps,and their endometrial polyps and adjacent normal endometrial tissues had been removed in the operations. ER and PR expression levels in endometrial polyps and adjacent normal endometrial tissues were detected by immunohistochemical assay （IHCA）. Results. The expression of ER was higher whereas the expression of PR was lower in endometrial polyps than those in the adjacent normal endometrial tissues （P〈0.05）. Conclusion. The abnormal expressions of ER and PR might be involved in the pathogenesis of endometrial polyps.

关 键 词：子宫内膜息肉 雌激素受体 孕激素受体 

分 类 号：R711.32[医药卫生—妇产科学] R711.74[医药卫生—临床医学]