心肌肽素对大鼠心脏缺血-再灌注损伤的预防作用  

Preventive Effect of Cardiomyopeptidin on Rat Heart Injured by Ischemia Reperfusion

作　　者：杨联萍[1] 万华印[1] 孔祥平[1] 吴艳[2] 腾健 范礼理[2] 

机构地区：[1]中国人民解放军第458医院传染病中心分子生物学科,广东广州510602 [2]中国医学科学院

出　　处：《中国中药杂志》2000年第2期105-107,共3页China Journal of Chinese Materia Medica

基　　金："九五"国家重点科技攻关项目!96 ;90 2 0 1 0 4

摘　　要：目的 :研究小分子多肽类物质心肌肽素对大鼠心脏缺血 再灌注损伤的预防作用。方法 :在大鼠冠脉结扎致心肌缺血 再灌注损伤模型上 ,观察心肌肽素预防性给药对缺血大鼠血浆中肌酸磷酸激酶 (CPK)、乳酸脱氢酶 (LDH)活性及脂质过氧化物终产物 (MDA)含量的影响。结果 :心肌肽素预防性给药能明显降低血浆CPK ,LDH的活性与MDA含量 ,其作用具有明显的量效关系。结论 :心肌肽素对心脏缺血 再灌注损伤有预防作用 ,这可能与其减少心肌酶的释放及抗心肌脂质过氧化有关。Objective:To investigate the preventive effect of cardiomyopeptidin of small molecular weight polypeptide on rat hearts injured by ischemia reperfusion.Methods:In a rat model injured by ischemia reperfusion in the heart,observation was made on the influence of cardiomyopeptidin on the activities of creatine kinase(CK)and lactate dehydrogenase(LDH),as well as on the content of MDA in plasma after the preventive drug was used.Results:Cardiomyopeptidin could obviously prevent the injury caused by ischemia reperfusion,reduce the activities of CK and LDH and the content of MDA in a dose dependentmanner.Conclusion:Cardiomyopeptidinhas a preventive effect on myocardium injured by ischemia reperfusion and this may be related to its reducing the release of myocardial enzyme and anti lipoperoxidation. [

关 键 词：多肽 心肌肽素 再灌注损伤 心肌酶 心肌缺血 

分 类 号：R285[医药卫生—中药学]