麝香乌龙丸对佐剂性关节炎大鼠滑膜组织形态及MIF ICAM-1表达的影响  

The Effect of Shexiang Wulong Pill on Morphology and Expression of MIF,ICAM-1 in Synovium of Rats with Adjuvant Arthritis

作　　者：王鹏飞[1] 毕东敏[1] 张爱国[1] 袁强[1] 陈守中[1] 易永泽[1] 王志文[1] 

机构地区：[1]河北联合大学附属医院,河北唐山063000

出　　处：《四川中医》2012年第6期48-50,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察麝香乌龙丸对佐剂性关节炎(AA)大鼠滑膜组织形态及巨噬细胞移动抑制因子(MIF)、细胞间粘附分子-1(ICAM-1)表达的影响,探讨麝香乌龙丸的抗炎作用是否与调节以上两种因子的表达有关。方法:建立AA大鼠模型,分正常组、模型组、麝香乌龙丸低剂量组、麝香乌龙丸高剂量组进行研究,HE染色观察关节滑膜组织形态学变化,免疫组织化学方法检测MIF、ICAM-1的表达。结果:麝香乌龙丸低剂量组、高剂量组均能减轻关节滑膜病理积分,均能降低MIF、ICAM-1在AA大鼠滑膜组织的表达,与模型组比较差异有统计学意义(P<0.05),麝香乌龙丸低剂量组和高剂量组比较差异无统计学意义。结论:麝香乌龙丸抑制AA大鼠炎症进展的作用机制与调节MIF、ICAM-1的表达有关。Objectives ： To observe the effects of Shexiang Wulong Pill on morphology of the synovial membrane and expres- sion of macrophage migration inhibitory （MIF） and intercellular adhesion molecule-1 （ ICAM-1 ） in synovial membrane of adjuvant arthritis rats, and explore whether the mechanism of anti-inflammatory were concerned-with those two factors and adjustment of the expression. Methods： Establishing adjuvant induced arthritis rats as experimental model, divided into normal group, model group, Shexiangv Wulong low and high dosages group randomly. HE dyes and observing the joint-synovium pathological change, detecting the expression level of MIF and ICAM-1. Results： The Ahexiang Wulong Pill group could reduce joint synovial patho- logical score and the expression of MIF, ICAM-1 （P〈0.05）. Compared with Shexiang Wulong low-dose group and high-dose group, there were no differences. Conclusion： Shexiang Wulong Pill can restrain the inflammation progress of experimental rheumatoid arthritis rat, the mechanism has related to the adjustment of expression of MIF and ICAM-1.

关 键 词：麝香乌龙丸 佐剂性关节炎 类风湿关节炎 巨噬细胞移动抑制因子 细胞间粘附分子-1 

分 类 号：R285.5[医药卫生—中药学]