Hypoxic preconditioning in an autohypoxic animal model  

作　　者：Guo Shao Guo-Wei Lu 

机构地区：[1]Medical School,Lishui University,Lishui 323000,China [2]Institute for Hypoxia Medicine,Department of Neurobiology,Capital Medical University,Beijing 100069,China [3]School of Basic Medical Sciences,Department of Neurobiology,Capital Medical University,Beijing 100069,China [4]Biomedicine Research Center and Basic Medical College,Baotou Medical College,Baotou 014030,China

出　　处：《Neuroscience Bulletin》2012年第3期316-320,共5页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (3967087, 81060212, and 81160244);the Beijing Natural Science Foundation (7962009);the China Postdoctoral Science Foundation (20080430851);the Science Foundation of Shandong Province, China (ZR2010HM029);the Inner Mongolia Science Foundation (2010BS1104)

摘　　要：Hypoxic preconditioning refers to the exposure of organisms, systems, organs, tissues or cells to moderate hypoxia/ischemia that results in increased resistance to a subsequent episode of severe hypoxia/ischemia. In this article, we review recent research based on a mouse model of repeated exposure to autohypoxia. Pre-exposure markedly increases the tolerance to or protection against hypoxic insult, and preserves the cellular structure of the brain. Furthermore, the hippocampal activity amplitude and frequency of electroencephalogram, latency of cortical somatosensory-evoked potential and spinal somatosensory-evoked potential progressively decrease, while spatial learning and memory improve. In the brain, detrimental neurochemicals such as free radicals are down-regulated, while beneficial ones such as adenosine are up-regulated. Also, antihypoxia factor（s） and gene（s） are activated. We propose that the tolerance and protective effects depend on energy conservation and plasticity triggered by exposure to hypoxia via oxygen-sensing transduction pathways and hypoxia-inducible factor-initiated cascades. A potential path for further research is the development of devices and pharma-ceuticals acting on antihypoxia factor（s） and gene（s） for the prevention and treatment of hypoxia and related syndromes.Hypoxic preconditioning refers to the exposure of organisms, systems, organs, tissues or cells to moderate hypoxia/ischemia that results in increased resistance to a subsequent episode of severe hypoxia/ischemia. In this article, we review recent research based on a mouse model of repeated exposure to autohypoxia. Pre-exposure markedly increases the tolerance to or protection against hypoxic insult, and preserves the cellular structure of the brain. Furthermore, the hippocampal activity amplitude and frequency of electroencephalogram, latency of cortical somatosensory-evoked potential and spinal somatosensory-evoked potential progressively decrease, while spatial learning and memory improve. In the brain, detrimental neurochemicals such as free radicals are down-regulated, while beneficial ones such as adenosine are up-regulated. Also, antihypoxia factor（s） and gene（s） are activated. We propose that the tolerance and protective effects depend on energy conservation and plasticity triggered by exposure to hypoxia via oxygen-sensing transduction pathways and hypoxia-inducible factor-initiated cascades. A potential path for further research is the development of devices and pharma-ceuticals acting on antihypoxia factor（s） and gene（s） for the prevention and treatment of hypoxia and related syndromes.

关 键 词：hypoxia hypoxic preconditioning adaptive medicine 

分 类 号：Q959.802[生物学—动物学] TS275.4[轻工技术与工程—农产品加工及贮藏工程]