5-氟尿嘧啶类脂囊泡药动学和组织分布研究  

Study on pharmacokinetic and tissue distribution in mice of 5-flurouracil niosomes

作　　者：袁悦[1] 王觅[1,2] 谌红丹[1] 车鑫[1] 赵琨[1] 王晶[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]河北省中医院药剂科,河北石家庄500011

出　　处：《东北师大学报（自然科学版）》2012年第2期99-102,共4页Journal of Northeast Normal University(Natural Science Edition)

基　　金：辽宁省博士启动基金资助项目(20081035);沈阳市科技局资助项目(1081231-1-00);辽宁省企业博士后项目(bsh2010042)

摘　　要：用非离子表面活性剂制备5-氟尿嘧啶(5-Fu)囊泡,并对其进行了小鼠体内药动学和组织分布的研究.采用薄膜分散法制备5-Fu的类脂囊泡,以5-Fu水溶液为对照,尾静脉注射自制5-Fu囊泡和5-Fu水溶液,利用高效液相色谱法检测血浆和各组织中的5-Fu浓度,利用统计学方法计算了5-Fu在小鼠体内的药动学参数及小鼠的组织分布参数.与注射水溶液组相比,5-Fu囊泡组MRT值延长,AUC0～t值增加.组织分布结果显示:5-Fu囊泡在肝、肾中AUC值显著增加;5-Fu囊泡明显延长了5-Fu在体内的作用时间,比普通水溶液具有一定的缓释和提高生物利用度的作用.To study the preparation of 5-flurouracil （5-Fu） noisomes and the pharmacokinetics and tissue distribution in mice. 5-Fu noisomes were prepared using film dispersion method. 5-Fu noisomes and 5-Fu solution were carried out in mice by caudal vein iniection. 5-Fu concentrations of plasma and various tissues were detected by HPLC methods. Statistical methods were used to calculate the parameters of pharmacokinetics and tissue distribution in mice. Compared to the group of 5-Fu solution,MRT and AUC0-t of 5-Fu niosomes both were increased. Compared with 5-Fu solution, 5-Fu niosomes had a sustained release and a improved bioavailability.

关 键 词：5-氟尿嘧啶 类脂囊泡 药物动力学 组织分布 

分 类 号：O648[理学—物理化学]