四种胰岛素强化治疗方案对新诊断2型糖尿病患者血糖控制及血管内皮功能的影响  

Comparison of efficacies of four different intensive insulin therapies with regard to blood-glucose control and vascular endothelial function in patients with newly-diagnosed type 2 diabetes

作　　者：施慧玲[1] 李焱[1] 刘珊英[1] 梁颖[1] 肖辉盛[1] 

机构地区：[1]中山大学附属第二医院内分泌科,广州510120

出　　处：《中华内分泌代谢杂志》2012年第6期496-498,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：比较各方案的疗效和能否改善血管内皮功能。患者分为接受门冬胰岛素30、门冬胰岛素＋甘精胰岛素、普通短效人胰岛素＋中效人胰岛素或门冬胰岛素持续皮下输入4组。行指尖、静脉和动态血糖监测，统计胰岛素用量、费用，血管彩超评测血管内皮功能。达标后各方案血糖控制无显著差异；血管内皮功能无显著改善。各方案短期疗效相当；短期强化治疗未显著改善血管内皮功能。To compare the effects of four different intensive insulin therapies on blood glucose control and vascular endothelial function in newly-diagnosed type 2 diabetes. Patients were randomly divided to accept pre-meal insulin aspart 30 or pre-meal insulin aspart and glargine at bedtime or pre-meal Novolin-R and NPH at bedtime or continuous subcutaneous insulin aspart infusion. Capillary blood glucose determination and continuous glucose monitoring system were carried out, therapeutic time and total insulin dosage were recorded. Ultrasound was used to evaluate the vascular endothelial function. Glucose le~＇el, incidence of low glucose, potency ratio of the four groups were similar（ P〉0.05 ） ; FMD and N MD were not significantly improved （P = 0.718, P = 0. 065 ）. The short-term efficacy and safety of the four groups are similar. The short-term intensive insulin therapy has no obvious effect on vascular endothelial function.

关 键 词：糖尿病 2型 胰岛素强化治疗 血管内皮功能 

分 类 号：R587.1[医药卫生—内分泌]