生脉丹咀嚼片对高脂模型大鼠血脂和血液流变学的影响  

Effects of Shengmaidan Chewable Tablets on blood lipid and hemorheology in hyperlipedemic model rats

作　　者：曹亮[1] 邓奕[1] 丁岗[1,2,3] 王振中[1,2,3] 萧伟[1,2,3] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中药制药过程新技术国家重点实验室,江苏连云港222001 [3]江苏省企业院士工作站,江苏连云港222001

出　　处：《现代药物与临床》2012年第3期214-217,共4页Drugs & Clinic

基　　金：科技部重大新药创制项目(2011ZX09401-014)

摘　　要：目的观察生脉丹咀嚼片对高脂模型大鼠血脂及血液流变学的影响。方法 ig给予大鼠高脂乳剂,形成高脂模型,同时ig给予0.5、1.0、2.0g生药/kg的生脉丹咀嚼片,4周后检测血液中总胆固醇(TG)、三酰甘油(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及血黏度、血浆黏度、红细胞压积、红细胞聚集指数、红细胞变形指数等血流变学指标。结果生脉丹咀嚼片各剂量组均可以降低模型大鼠血清TC和LDL-C水平,其中2.0g生药/kg组与模型组比较具有统计学意义(P<0.01)。生脉丹咀嚼片0.5g生药/kg组还具有一定的降低模型大鼠血清TG的作用(P<0.01);同时生脉丹咀嚼片各给药组可以降低高血脂模型大鼠全血低切还原黏度、血浆黏度、红细胞压积及红细胞聚集指数(P<0.01),对红细胞变形指数无明显影响。结论生脉丹咀嚼片具有一定的降低高脂模型大鼠的血脂和改善血流变学的作用。Objective To observe the effects of Shengmaidan Chewable Tablets on blood lipid and hemorheology in hyperlipedemic model rats.Methods Hyperlipedemic models were established by ig administration with high fat emulsion,meanwhile the Shengmaidan Chewable Tablets were given in three dosages 0.5,1.0,and 2.0 g/kg.The blood levels of triglyceride（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,and low density lipoprotein cholesterol（LDL-C） were detected after four weeks.Whole blood viscosity,plasma viscosity,hematocrit,erythrocyte aggregation index,and index of erythrocyte deformability were determined at the same time.Results Shengmaidan Chewable Tablets could reduce the blood levels of TC and LDL-C.Compared with the model group,Shengmaidan Chewable Tablets high dosage（2.0 g/kg） group could reduce TC and LDL-C in rat serum obviously（P0.01）,low dosage（1.0 g/kg） group could reduce TG in rat serum obviously（P0.01）.Shengmaidan Chewable tablets could notably decrease low-shear reduced viscosity of whole blood,plasma viscosity,hematocrit,and erythrocyte aggregation index（P0.01）,while had no obvious effect on the index of erythrocyte deformability.Conclusion Shengmaidan Chewable Tablets shows clear improvement for the serum level of lipidemic and hemorrheologic exception in hyperlipedemic rats.

关 键 词：生脉丹咀嚼片 高脂模型 血液流变学 血脂 

分 类 号：R285.5[医药卫生—中药学] R286.2[医药卫生—中医学]