广西防城港地区壮族健康成年男性血清癌胚抗原参考区间调查  

Reference values for serum levels of carcinoembryonic antigen in Zhuang ethnic adult males from Fangchenggang area

作　　者：林丽文[1] 李山[1] 吕慧[1] 黄珊[1] 高勇[2] 谭爱花[3] 杨晓波[4] 秦雪[1] 莫曾南[3] 

机构地区：[1]广西医科大学第一附属医院临床医学实验部,南宁530021 [2]广西医科大学基因组与个性化医学研究中心,南宁530021 [3]广西医科大学第一附属医院泌尿外科,南宁530021 [4]广西医科大学公共卫生学院,南宁530021

出　　处：《重庆医学》2012年第17期1673-1674,1677,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(30945204);广西财政教育资助基金资助项目(2009GJCJ150)

摘　　要：目的建立广西防城港地区壮族健康成年男性血清癌胚抗原(CEA)的参考值范围。方法采集广西防城港地区健康成年男性空腹血清,使用罗氏Cabas E601型全自动电化学发光免疫分析系统测定血清CEA水平。结果符合纳入标准并排除极端值后,共纳入研究对象282例,血清CEA浓度呈正偏态分布,单侧95%置信区间为不大于5.12ng/mL(非参数法)或不大于5.16ng/mL(参数法)。血清CEA值与年龄和吸烟存在相关,而与体质量指数(BMI)和饮酒不相关。将研究对象按年龄或是否吸烟进行分层分别建立参考区间。结论该研究结果与国外报道的血清CEA的95%置信区间不尽相同,各地区实验室应该建立各自健康人群的参考值范围。Objective To establish the normal reference values for serum carcinoembryonic antigen （CEA） among the male Zhuang people of the Fangchenggang area in Guangxi. Methods Fasting serum samples were collected from adult males and the levels of serum CEA were detected by Roche Cobas E601 electrochemical immunoassay system. Results 282 subjects were selected in final analysis after screening and eliminating outlier. The distribution of serum CEA values was positively skewed and the oneside upper 95% reference values for serum CEA were 45.12 ng/mL（non-parametric method） or 45.16 ng/mL（parametric method）. Age and smoking, but not BMI or drinking, were associated with serum CEA values. Therefore, ageor smoking-dependent reference values were established. Conclusion The reference values for serum CEA in current study are different from previous study. It is suggested that every region should establish respective normal reference values for healthy persons.

关 键 词：血清癌胚抗原 成年男性 参考区间 

分 类 号：R446.1[医药卫生—诊断学]