四种耐药基因蛋白及Ki-67在浸润性乳腺癌组织中表达的临床意义  

The expression and clinical significance of Pgp,TS,GST-π,TopoⅡ and Ki-67 in invasive breast cancer biopsies

作　　者：肖秀丽[1] 郭晶晶[1] 龙汉安[1] 蒲霞[1] 郭庆喜[1] 

机构地区：[1]泸州医学院病理学研究室,四川泸州646000

出　　处：《泸州医学院学报》2012年第3期277-281,共5页Journal of Luzhou Medical College

摘　　要：目的:探讨Pgp、TS、GST-π、TopoⅡ和Ki-67在浸润性乳腺癌组织中的表达,并探讨其临床意义。方法:采用免疫组织化学Envision法检测267例乳腺癌患者Pgp、TS、GST-π、TopoⅡ和Ki-67的表达,分析它们与患者的临床病理特征的相关性。结果:乳腺癌患者Ki-67增殖指数为:27.73%±21.85%,Pgp、TS、GST-π、TopoⅡ的阳性率分别为69.29%、64.04%、23.60%、29.21%;Ki-67与肿块直径、ER、PR具有相关性;Pgp与肿块大小具有相关性;GST-π、TopoⅡ与ER、PR具有相关性;Pgp与TS、GST-π呈正相关性,TopoⅡ与TS呈负相关性,与Ki-67呈正相关性。结论:Pgp、TS、GST-π、TopoⅡ及Ki-67在乳腺癌的表达中存在一定的相关性,联合上述指标检测对乳腺癌患者的临床诊疗及预后具有重要意义。Objective ：To explore the expression and clinical significance of Pgp, TS, GST-π, Topo Ⅱ and Ki-67 in invasive breast cancer biopsies. Methods：The expressions of Pgp, TS, GST-π, Topo Ⅱ and Ki-67 in 267 specimens of invasive breast cancer were examined by Envision immunohistochemistry. The relationship between the expression of these five proteins and the clinicopathological characteristics and prognosis of breast cancer patients were analyzed. Results：Among 267 patients, the Ki-67 was 27.73% ＋21.85%, the positive rate of Pgp, TS, GST-π,and Topo II was 69.29%, 64.04%, 23.60% and 29.21%, respectively. There were significant correlations between Ki-67, GST-π, Topo Ⅱ expression and ER, PR expression; the Ki-67 expression and Pgp expression were associated with tumor size; Pgp expression was positively correlated with TS and GST-π expression; Topo Ⅱ expression was negatively related to TS expression, positively related to Ki-67expression. Conclusion：The expressions of Pgp, TS, GST-π, Topo Ⅱ and Ki-67 in breast cancer patients are correlated; combined detection is essential to clinical diagnosis, treatment and prognosis.

关 键 词：乳腺 癌 PGP TS GST-ar TopoⅡ KI-67 耐药性 

分 类 号：R977[医药卫生—药品]