七氟烷对兔定量药物脑电图δ频段功率百分比的影响  

Effect of sevoflurane on δ-band of quantitative pharmaco-electroencephalography in rabbits

作　　者：韩平平[1] 蔡慧明[1] 郭继龙[2] 吴克俭[3] 王琦[4] 王立伟[5] 戴体俊[6] 

机构地区：[1]徐州医学院药学院,江苏徐州221002 [2]徐州医学院附属医院麻醉科,江苏徐州221002 [3]徐州医学院附属医院脑电图室,江苏徐州221002 [4]徐州医学院第二附属医院神经内科,江苏徐州221002 [5]徐州市中心医院麻醉科,江苏徐州221002 [6]徐州医学院麻醉药理教研室,江苏徐州221002

出　　处：《中国药理学与毒理学杂志》2012年第3期310-313,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金资助项目(30872432);国家自然科学基金资助项目(30471657);国家自然科学基金资助项目(39970715);江苏省社会发展科技计划项目(BS 200054);徐州医学院药学院研究生科研创新计划项目(2010YKYCX011)~~

摘　　要：目的探讨七氟烷对兔定量药物脑电图(QPEEG)δ频段影响的量效关系和时效关系。方法 18只成年家兔随机分为七氟烷50,100和200μl·kg-1组,应用QPEEG,采用功率谱分析法,分析兔静注七氟烷前后δ频段功率百分比的变化。结果七氟烷50μl·kg-1对δ频段的功率百分比无明显影响;七氟烷100μl·kg-1使δ频段的功率百分比在各脑区30 s～10 min内增加(P<0.05);七氟烷200μl·kg-1使δ频段的功率百分比在各脑区30 s～10 min内显著增加(P<0.05,P<0.01);δ频段的功率百分比的改变与七氟烷剂量在30 s～10 min内均成显著正相关(r=0.734～0.944,P<0.01)。结论七氟烷以剂量依赖方式增加兔QPEEGδ频段的功率百分比,提示δ频段可能成为反映麻醉深度的指标。Abstract： OBJECTIVE To investigate the effect of sevoflurane on δ-band of quantitative pharmaco-electroencephalogram （QPEEG） in rabbits, and the dose-effect and time-effect relation-ships. METHODS Eighteen healthy rabbits were randomly divided into three groups （ n = 6 ） , sevoflurane 50, 100 and 200 μl. kg-1 The EEG samples were obtained prior to and at regular intervals（0, 0.5, 1, 2, 3, 5 and 10 min） within 10 min following the administration of sevoflurane. EEG activity was processed with power spectral analysis. RESULTS The percentage of δ-band power showed no significant changes in sevoflurane 50 μl.kg-1 group but increased and reached a significant level（P 〈0. 05）in sevoflurane 100 and 200 μl.kg-1 groups after 30 s- 10 min in all regions of the brain, especially in sevoflurane 200 μl.kg-1 group. Changes in δ-band power 30 s - 10 min following adminitration of sevoflurane were correlated with the dose of sevoflurane （r = 0. 734 - 0. 944,P 〈0.01 ）. CONCLUSION With the increasing dose of sevoflurane, the percentage of δ-band power progressively increases, suggesing that δ-band power can be an effective means of monitoring the depth of anesthesia.

关 键 词：七氟烷 Δ频段 定量药物脑电图 麻醉 

分 类 号：R965[医药卫生—药理学]