细胞色素氧化酶P450家族在中药毒性研究中的应用进展  

Progress in cytochrome P450 enzyme in toxicity of traditional Chinese medicines

作　　者：廖乃顺[1] 陈文列[1] 

机构地区：[1]福建中医药大学中西医结合研究院中药药理国家中医药三级科研实验室,福建福州350122

出　　处：《中国药理学与毒理学杂志》2012年第3期402-405,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：陈可冀中西医结合发展基金(CKJ2010034)~~

摘　　要：细胞色素氧化酶P450(CYP)是最重要的药物代谢酶,多种中药能抑制或诱导CYP3A,CYP2C等亚型活性,而影响中药代谢,其中抑制作用是药物不良反应的主要原因;CYP1A2和CYP2E1等参与了中药前毒物的活化引起毒性反应。CYP参与中药代谢性相互作用,故可通过对CYP抑制或诱导作用的分析,研究中药配伍减毒作用或配伍禁忌的毒性(增毒)作用;应重视研究中西药合用引起不良反应的CYP作用。本文综述了CYP在中药毒性研究中的应用概况,进一步展望CYP的应用前景,以期对中药毒性研究提供新思路。Cytochrome P450 （CYP） enzyme is one of the most important drug metabolism enzymes. Herbs can inhibit or induce the activity of CYP subtypes （ CYP3A and CYP2C, etc）. The inhibitory effect on drug metabolism is the main cause of adverse drug reactions. It has been found that CYP, including CYP1A2 and CYP2E1, meta-bolically activate toxicants. CYP affects drug metabolic interactions, which has been used to explore toxicity of Chinese herbal compatibility or incompatibility. The study on CYP activities in adverse drug reactions of Chinese herbs combined with Western medicine is of great important. This paper reviews the application of CYP in studies on the toxicity of traditional Chinese medicines.

关 键 词：细胞色素P450酶系统 中草药 毒性作用 

分 类 号：R285[医药卫生—中药学]