头孢噻呋钠-壳聚糖纳米粒的制备及相关性质的研究  

Preparation and characterization of ceftiofur sodium-chitosan nanoparticles

作　　者：符华林[1] 黄平全 付强[1] 杨元国 张伟[1] 唐文[1] 

机构地区：[1]四川农业大学动物医学院动物疫病与人类健康四川省重点实验室,四川雅安625014 [2]蓬溪县畜牧局,四川蓬溪629100 [3]四川金瑞克动物药业有限公司,四川自贡643010

出　　处：《中国兽医科学》2012年第6期637-641,共5页Chinese Veterinary Science

基　　金：教育部"长江学者和创新团队发展计划"创新团队项目(IRT0848)

摘　　要：为了延长头孢噻呋钠的作用时间,采用离子交联法制备头孢噻呋钠-壳聚糖纳米粒,研究其形态、粒径、载药量、包封率和体外释药特性。结果显示,经优化工艺所得的纳米粒形态规整,近圆形,平均粒径为179.4±39.5nm,平均包封率为84.31%±2.53%,平均载药量为6.69%±0.18%。体外释放试验表明,原料药在放入释放介质后第4小时释放率达到90%以上,而纳米粒在此时药物仅释放60%。结果表明,该纳米粒制备工艺可行,对头孢噻呋钠具有明显的缓释效果。To prolong the action time of ceftiofur sodium, ceftiofur sodium-chitosan nanoparticle（CNP） were prepared by ionic crosslinking method. Morphology, particle size and distribution, encapsulation efficiency and drug loading rate were investigated. In result, the appearance of prepared CNP was regular with the diameter being of 179.4±39.5 nm. The encapsulation efficiency and drug-loading rate were 84.31% ±2.53 % and 6.69 %±0.18 % respectively. The in vitro release experiment showed that the ceftiofur sodium was released above 90% at 4 h post-treatment,meanwhile only 60% was released from CNP. In conclusion, the CNP preparation procedure is feasible and CNP have obvious sustained-release effect.

关 键 词：头孢噻呋钠 壳聚糖 纳米粒 质量评价 

分 类 号：S859.796[农业科学—临床兽医学]