高血压患者血压参数与记忆功能的相关性研究  

Relationship between blood pressure level and cognitive impairment in patients with hypertension

作　　者：王建辉[1] 陈长香[2] 

机构地区：[1]唐山市工人医院,河北唐山063000 [2]河北联合大学护理与康复学院

出　　处：《临床心血管病杂志》2012年第6期427-429,共3页Journal of Clinical Cardiology

基　　金：河北省科技厅科技支撑项目(No:2009276103D-7)

摘　　要：目的:探讨高血压患者的收缩压、舒张压及脉压参数与其记忆功能的相关性,为进一步采取干预措施提供可靠依据。方法:收集唐山市工人医院高血压患者196例为观察组,应用英国Rivermead康复中心设计的行为记忆测验第2版(RBMT-Ⅱ,2003年)对其进行记忆功能测评;应用方差分析、线性相关和逐步回归分析检验收缩压、舒张压及脉压水平与记忆功能的相关性。结果:不同分级高血压患者的记忆障碍患病率及程度随着血压水平的提高而加重(χ2=28.696,P<0.01),高血压3级患者的RBMT-Ⅱ评分与高血压1、2级患者比较,在回忆姓名、回忆被藏物品、脸部再认、路线延迟回忆、定向单项评分及总标准分等6项评分均差异有统计学意义(均P<0.05);随着收缩压水平及脉压水平的升高,RBMT-Ⅱ评分呈下降趋势(P<0.05);舒张压水平与RBMT-Ⅱ评分无相关性。结论:高血压患者的收缩压参数及脉压参数影响记忆功能,尤其以脉压参数明显。应加强脉压参数的调节与控制,以维持和提高高血压患者的记忆功能。Objective：To explore the relationship between systolic blood pressure（SBP）,pulses pressure（PP）,diastolic blood pressure（DBP） level and cognitive impairment in patients with hypertension,and provide credible foundation for interventions on cognitive impairment. Method：One hundred and ninety-six patients with hypertension in Tangshan Worker’s Hospital were selected and surveyed with questionnaires.Cognitive function was measured by the Rivermead Behavioural Memory Test Second Edition（RBMT-Ⅱ,2003）.The One-Way ANOVA and linear regression was used to find the statistical significance between SBP,PP,DBP level and cognitive impairment. Result：The morbidity of memory disorder among patients with hypertension was higher and more serious with increasing blood pressure level（χ2=28.696,P〈0.01）.Among different systolic pressure groups,RBMT-Ⅱ total scores,Recall name,Remember storing article,Recall faces,Delayed Route,orientation score decreased with increasing blood pressure level（P〈0.05）.Linear regression analysis showed that SBP,PP level were positively related to the morbidity of cognitive impairment（P〈0.01）,and there was no relationship between DBP level and the morbidity of cognitive impairment. Conclusion：The SBP level and PP level in patients with hypertension had significant impact on cognitive function.Especially the PP level impacted the cognitive function much more seriously.Lower the level of PP effectively is a strong determinant of lowering the morbidity of cognitive impairment.

关 键 词：高血压 记忆功能障碍 

分 类 号：R544.1[医药卫生—心血管疾病]