心肌尔康对两肾一夹诱导高血压大鼠靶器官损伤的影响  

Effects of Xinjierkang on Two Kidney One Clip-induced Hypertension and Target Organ Injury in Rats

作　　者：高杉[1] 黄玲玲[1] 汪星辉[1] 俞婷婷[1] 杜苏明[1] 郭言伟[1] 

机构地区：[1]安徽医科大学基础医学院药理学教研室,安徽合肥230032

出　　处：《中药材》2012年第4期591-595,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(81073088);教育部高等学校博士学科点专项科研基金资助(20103420120002)

摘　　要：目的:研究心肌尔康对两肾一夹诱导高血压大鼠靶器官损伤的影响。方法:采用两肾一夹诱导高血压大鼠动物模型。实验分为假手术组、模型组、心肌尔康组和福辛普利组。第8周末,颈动脉插管测量血压和心功能,计算小鼠心脏指数,HE染色和/或V-G染色观察心脏、胸主动脉及肾脏病理形态学改变。结果:与假手术组比较,两肾一夹高血压模型组大鼠心脏舒缩功能明显受到损伤,心脏指数、心肌细胞横截面积、心肌纤维化、肾小球面积明显升高,胸主动脉发生明显重构。与模型组比较,心肌尔康和福辛普利能明显改善大鼠心功能,改善心血管重构和肾小球肥大。结论:心肌尔康能明显改善两肾一夹高血压大鼠心功能、心血管重构和肾小球肥大。Objective ： To investigate the effects of Xinjierkang on two kidney one clip -induced hypertension and target organ injury in rats. Methods：Two kidney one clip-induced hypertension rats model was established. Rats were divided into control group, model group,Xinjierkang group, and fosinopril group. At the end of 8th w,the hemodynamics indexes were recorded. The cardiac hypertrophy index was expressed as heart weight/body weight （HW/BW） ,the histological changes of heart, aorta and kidney were investigated by HE and/or Van Gieson stain. Results ： Compared with control group, the heart systolic and diastolic function were impaired, the heart weight index, cardiomyocytes cross section area（ CSA）, cardiac collagen deposition, vascular remodeling index and glomerulus area were increased markedly in model group rats. Administration of Xinjierkang and fosinopril markedly ameliorated hemodynamic indexes, inhib- ited the elevation of HW/BW ratio, CSA of cardiomyocytes, vascular remodeling index and glomerulus hypertrophy, decreased collagen deposition in heart. Conclusion：Xinjierkang has protective effects against two kidney one clip-induced hemodynamic impairment, cardi- ovascular remodehng and glomerulus hypertrophy in rats.

关 键 词：心肌尔康 两肾一夹 心室重构 血管重构 心功能 肾小球肥大 

分 类 号：R285.5[医药卫生—中药学]