索利那新联合坦索罗辛治疗经尿道前列腺电切术后膀胱过度活动症临床效果观察  

The clinical effects observing of Solifenacin combined Tamsulosin in the treatment of overactive bladder after TURP

作　　者：廖波[1] 邓显忠[1] 曾德朗[1] 姜果[1] 余晓东[1] 

机构地区：[1]川北医学院附属医院泌尿外科,南充637000

出　　处：《中国实用医药》2012年第15期20-21,共2页China Practical Medicine

摘　　要：目的探讨索利那新联合坦索罗辛治疗经尿道前列腺电切术(TURP)后膀胱过度活动症的临床疗效与安全性。方法临床采集31例TURP术后膀胱过度活动症患者,予以索利那新5mg及坦索罗辛0.2mg口服,1次/d,连续7～10d。治疗前后行膀胱过度活动症评分(OABSS),国际前列腺症状评分(IPSS)和生活质量评分(QOL),以三项评分均数为评价指标结合药物副反应发生率评价此治疗方案的有效性和安全性。结果 31例患者平均服药时间为(5±3)d,治疗后OABSS评分平均降低8.14分(P<0.01),且均≤4分,IPSS评分平均降低16.67分(P<0.01),QOL评分平均降低2.09分(P<0.01)。药物副反应发生率为3%(1例患者出现口渴症状)。结论索利那新联合坦索罗辛治疗TURP术后膀胱过度活动症有显著效果,同时有较高的安全性。Objective To study the efficacy and safety of Solifenacin combined Tamsulosin in the treatment of overactive bladder after TURP.Methods Collected 31 cases overactive bladder patients who had received TURP,treated with solifenacin 5 mg and tamsulosin 0.2 mg,take orally once per day,and continued for 7~10 days.The overactive bladder syndrome score（OABSS）,the international prostate symptom score（IPSS） and quality of life score（QOL） were evaluated before and after treatment and also record the adverse drug reaction,combined the average score and the adverse drug reaction incidence to assess the efficacy and safety of the treatment.Results The average treating time of 31 cases is（5±3） days,the OABSS average score reduced 8.14（P0.01,and every score ≤4）,IPSS average score reduced 16.67（P0.01）,QOL average score reduced 2.09（P0.01）.The adverse drug reaction incidence was 3%（1 case with thirsty symptoms）.Conclusion The clinical effects of solifenacin combined tamsulosin in the treatment of overactive bladder after TURP were obviously,and have a higher security.

关 键 词：索利那新 坦索罗辛 膀胱过度活动症 经尿道前列腺电切术 

分 类 号：R699[医药卫生—泌尿科学]