HPV感染在尖锐湿疣及外阴和宫颈上皮内瘤变病变中的分布  

The distribution of HPV infection in the condylomata acuminate and the vulva and cervix intraepithelial neoplasia

作　　者：王力[1] 李振丰[2] 吴勇军[2] 唐仪[2] 李筝[2] 赵毅[2] 伍镇江[2] 

机构地区：[1]怀化医学高等专科学校附属怀化市第三人民医院皮肤性病科,湖南怀化418000 [2]湘潭市第一人民医院病理科,湖南湘潭411101

出　　处：《中国医学工程》2012年第4期22-24,共3页China Medical Engineering

基　　金：湘潭市科技计划项目(ZJ103004)

摘　　要：目的探讨HPV感染在尖锐湿疣和上皮内瘤变(包括外阴和宫颈)病变中的分布情况。方法通过HPV基因分型检测对330例尖锐湿疣和250例上皮内瘤变病变进行了HPV6、11、42等低危型及16、18、31、33、39、45、52、56、58等高危型DNA检测。结果 330例的尖锐湿疣组织中:274例为HPV6/11型(83.0%),46例为HPV16/18型(13.9%);250例上皮内瘤变病变组织中,8例为HPV6/11型(3.2%),167例为HPV16/18型(66.8%)。结论尖锐湿疣感染的HPV类型以HPV6、11为主,上皮内瘤变病变HPV类型以HPV16、18为主。[ Objective ] To investigate the distribution of HPV infection in the condylomata acuminate and intraepithelial neoplasia（ including the vulva and cervix）. [ Methods] Detect HPV6,11,42 low - risk type and 16,18,31, 33,39,45,52,56,58 high -risk DNA in 330 cases condylomata acuminate and 250 cases intraepithelial neoplasia lesions by HPV genotyping. [ Results] Out of 330 cases condylomata acuminate organization： 274 cases were HPV6/ll type （83.0%）, 46 cases were HPV16/18 type （ 13.9% ） ; of the 250 intraepithelial neoplasia group, 8 cases were HPV6/11 type （3.2%）, 167 cases were HPV16/18 type （66.8%）. [ Conclusion] The main HPV types of condylomata acuminate infection were HPV6, 11; intraepithelial neoplasia infected HPV types were HPV16, 18 based.

关 键 词：人乳头瘤病毒(HPV) 尖锐湿疣 上皮内瘤变 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]