细菌性阴道病微生态与益生菌  

Microecology,bacterial vaginosis and probiotics

作　　者：沈定树[1] 梁平[1] 彭敏飞[1] 

机构地区：[1]台州医院检验科,浙江台州317000

出　　处：《中国微生态学杂志》2012年第6期570-572,共3页Chinese Journal of Microecology

摘　　要：细菌性阴道病(BV)是育龄妇女阴道炎的最常见原因,其特征是栖居在阴道内的乳酸杆菌减少导致阴道菌群平衡失调的复杂变化。用乳酸杆菌替代抗生素是治疗BV的一种有效的治疗措施。乳酸杆菌产生过氧化氢、乳酸、杆菌素能抑制引起BV的细菌生长。多胺在BV的病理机制中有重要作用。本研究拟综述BV患者阴道菌群的变化,免疫防御反应,阴道乳酸杆菌对BV的影响,多胺的意义,益生菌在治疗选择中的作用。Bacterial vaginosis is the most common cause of vaginitis in women of childbearing age. The disorder represents a complex change in vaginal flora characterized by a reduction in the prevalence and concentration of lactobacilli. Probiotics enriched in lactobacilli have been proposed as an effective and alternative tool to antibiotics for the treatment of bacterial vagino- sis. In vitro studies have suggested that certain specific strains of lactobacilli are able to inhibit the adherence of Gardnerella vaginails to the vaginal epithelium and/or produce H202, lactic acid and/or bacteriocins, which inhibit the growth of bacteria cau- sing BV. This is of outstanding interest due to the central role of polyamines in the pathogenesis of bacterial vaginosis.

关 键 词：细菌性阴道病 乳酸杆菌 多胺 益生菌 

分 类 号：R711.31[医药卫生—妇产科学]