白介素-6和内皮素-1在慢性阻塞性肺疾病合并肺动脉高压患者中的表达  

Expressions of interleukin-6 and endothelin-1 in patients with chronic obstructive pulmonary disease combined with pulmonary hypertension

作　　者：王同生[1] 毛毅敏[1] 孙玉霞[1] 娄源杰[1] 

机构地区：[1]河南科技大学第一附属医院呼吸科,洛阳市471000

出　　处：《实用医学杂志》2012年第12期1977-1979,共3页The Journal of Practical Medicine

基　　金：河南省医学科技攻关项目(编号:200803029)

摘　　要：目的:研究白介素-6(IL-6)和内皮素-1(ET-1)在慢性阻塞性肺疾病(COPD)合并肺动脉高压(PH)患者和COPD无PH患者中的表达水平。方法:66例COPD合并PH患者和64例COPD无PH患者,检测IL-6和ET-1水平,心脏多普勒检测肺动脉收缩压力(PASP),PASP≥36mmHg为PH,检查肺功能、动脉血气、6min步行距离。结果:COPD合并PH患者IL-6和ET-1水平高于COPD无PH患者,分别是中位数3.6pg/L(四分位间距2.3～4.9pg/L)与中位数2.3pg/L(四分位间距1.2～3.7pg/L),差异有统计学意义(z=-2.756,P<0.01);中位数4.7pg/L(四分位间距,1.8～7.9pg/L)与中位数1.5pg/L(四分位间距,0.9～3.7pg/L),差异有统计学意义(z=-2.945,P<0.01)。所有患者IL-6和ET-1水平呈正相关(r=0.782,P=0.001);肺动脉压力水平与IL-6(r=0.381,P=0.001)和ET-1(r=0.529,P=0.001)水平有关;6min步行距离分别和氧分压负相关(r=-0.728,P=0.032),和ET-1正相关(r=0.625,P=0.001),和IL-6正相关(r=0.461,P=0.001)。结论:IL-6和ET-1可能与COPD并PH形成有关,具体机制有待进一步研究。Objective To investigate the expressions of interleukin-6 （IL-6） and endothelin-1 （ET-1） in patients with chronic pulmonary disease （COPD） combined with or without pulmonary hypertension （PH）. Methods The expressions of IL-6 and ET-1 in 66 patients with COPD combined with PH and 64 patients with COPD but without PH were detected. PH was defined as a systolic pulmonary artery pressure （PASP） I〉 36 mmHg assessed by Doppler echocardiography. The lung function, arterial blood gases, 6-minute walking distance were detected. Results The expressions of IL-6 and ET-1 in patients with COPD and PH were significantly higher than those in patients with COPD but without PH [median IL-6 levels were 3.6 pg/L （quartile range 2.3-4.9 pg/L） and 2.3 pg/L （quartile range 1.2-3.7 pg/L）, z = -2.756, P 〈 0.01 ; median ET-1 levels were 4.7 pg/L （quartile range 1.8-7.9 pg/L） and 1.5 pg/L （quartile range 0.9-3.7 pg/L）, z = -2.945, P 〈 0.01 ]. The expressions of IL-6 and ET-1 were positively correlated （r = 0.782, P = 0.001 ）. For COPD patients, PASP was significantly correlated with the levels of IL-6 （r = 0.381, P = 0.001） and ET-1 （r = 0.529, P = 0.001）. The 6-rain walking distance （6-MWD） was negatively correlated to PaO2 （r = -0.728, P = 0.032） and was positively correlated to the levels of ET-1 （r = 0.625, P= 0.001） and IL-6 （r = 0.461, P= 0.001）. Conclusions IL-6 and ET-1 may correlate with PH in patients with COPD, but the specific mechanisms are waiting for further study.

关 键 词：肺疾病 慢性阻塞性 肺动脉高压 白介素-6 内皮素-1 

分 类 号：R563.9[医药卫生—呼吸系统]