吸烟对慢性阻塞性肺疾病患者血清及肺泡灌洗液中肿瘤坏死因子-α及干扰素-γ的影响  

Effect of smoking on the levels of TNF-α and IFN-g in sera and BALF in patients with chronic obstructive pulmonary disease

作　　者：张念[1] 徐清[1] 陈菁[1] 杨硕[1] 刘梦琳[1] 聂红[1] 孙洁民[1] 

机构地区：[1]武汉市第一医院,430022

出　　处：《实用医学杂志》2012年第12期1980-1982,共3页The Journal of Practical Medicine

基　　金：湖北省自然科学基金资助项目(编号:2005ABA210)

摘　　要：目的:评价吸烟对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者急性期、稳定期血清及肺泡灌洗液中肿瘤坏死因子-α(TNF-α)及干扰素-γ(IFN-γ)的影响。方法:分别测定正常对照组、非吸烟COPD组、持续吸烟COPD组及戒烟COPD组患者急性期、稳定期血清及肺泡灌洗液中TNF-α及IFN-γ的水平,并对各组血清及肺泡灌洗液中TNF-α及IFN-γ水平分别进行比较。结果:COPD患者无论在急性期还是稳定期,肺泡灌洗液中TNF-α水平较正常对照组高(P<0.05)。其中,持续吸烟的COPD患者肺泡灌洗液中TNF-α水平较非吸烟COPD组及戒烟COPD组高(P<0.05)。急性期及稳定期COPD患者血清中TNF-α水平较正常组高(P<0.05)。急性期及稳定期COPD患者血清及肺泡灌洗液中IFN-γ水平均较正常组高(P<0.05)。其中,持续吸烟的COPD患者肺泡灌洗液中IFN-γ水平较非吸烟COPD及戒烟COPD患者均高(P<0.05)。结论:COPD患者急性期及稳定期存在TNF-α及IFN-γ介导的全身及气道局部炎症反应增强。持续吸烟的COPD患者气道局部的炎症反应增强最显著,而戒烟的COPD患者较持续吸烟的COPD患者该炎症反应减弱。Objective To investigate the effects of smoking on the levels of TNF-α and IFN-g in sera and BALF in patients with chronic obstructive pulmonary disease （COPD）. Methods Patients enrolled were divided into 4 groups： normal control group, non-smoking COPD group, smoking COPD group, and smoking cessation COPD group. Levels of TNF-α and IFN-g in sera and BALF in all the patients were determined. Results Levels of TNF-α and IFN-g in sera and BALF in patients with COPD in acute and stable periods were higher than those in normal control group （P 〈 0.05）. Levels of TNF-α and IFN-g in BALF in acute and stable periods in smoking COPD group were significantly higher than those in non-smoking COPD group and smoking cessation COPD group （P 〈 0.05）. Conclusions Patients with COPD present enhanced systemic and airway inflammation mediated by TNF-α and IFN-g in both acute and stable phases. Smoking COPD patients present significantly enhanced airway inflammation, which seems be lowered after smoking cessation.

关 键 词：肺疾病 慢性阻塞性 吸烟 TNF-Α IFN-Γ 

分 类 号：R563.9[医药卫生—呼吸系统]