蝙蝠葛中的化学成分(英文)  

Chemical constituents of Menispermum dauricum

作　　者：陈建勇[1] 谢郁峰[2] 周天锡[1] 秦国伟[1] 

机构地区：[1]中国科学院上海生命科学院上海药物研究所,上海201203 [2]广东药学院药科学院,广州510006

出　　处：《中国天然药物》2012年第4期292-294,共3页

基　　金：supported by the National Natural Sciences Foundation of China (No. 30470187)~~

摘　　要：目的:研究中药蝙蝠葛的化学成分。方法:应用硅胶和凝胶反复柱层析进行分离,分得成分用波谱分析和理化性质对照进行结构鉴定。结果:分离鉴定出11种成分,分别为dauricumine(1),dauricumidine(2),acutuminine(3),physcion(4),blumenolC(5),blumenolA(6),N-transferuloyltyramine(7),vanillin(8),β-sitostenone(9),β-sitosterol(10),和daucosterol(11)。结论:含氯生物碱1和2为首次从天然来源中分得,含氯生物碱3的NMR数据和立体结构为首次报道,化合物4-11均为首次从本植物中分到。AIM： To study the chemical constituents of Menispermum dauricum DC. METHODS： Compounds were isolated by repeated chromatography on silica gel and Sephadex LH-20. The structures were identified by spectral analysis and comparison with literature data. RESULTS： Eleven compounds were obtained and identified as dauricumine （1）, dauricumidine （2）, acutuminine （3）, physcion （4）, blumenol C （5）, blumenolA （6）, N-trans feruloyltyramine （7）, vanillin （8）, β-sitostenone （9）, β-sitosterol （10）, and dancosterol （11）. CONCLUSION： All compounds were known, but isolated from the plant for first time. Compounds 1 and 2 were chlorine-containing alkaloids obtained from natural source for the first time. The stereochemistry of 3 was determined for first time.

关 键 词：蝙蝠葛 含氯生物碱 化学成分 

分 类 号：R284.1[医药卫生—中药学]