沙煲暗罗根的化学成分(英文)  

Chemical constituents from the roots of Polyalthia obliqua

作　　者：王吉鸿[1] 纪明慧[1] 舒火明[1,2] 陈光英[1] 宋小平[1] 王菁[1] 

机构地区：[1]海南师范大学,省部共建-热带药用植物化学教育部重点实验室,海口571158 [2]海南经贸职业技术学院,海口571127

出　　处：《中国天然药物》2012年第4期303-306,共4页

基　　金：supported by the National Natural Science Foundation of China (Nos. 81160391,20862005);Natural Science Foundation of Hainan (No. 211015)~~

摘　　要：目的:对沙煲暗罗根的化学成分进行研究。方法:运用硅胶和Sephadex LH-20柱色谱,以及制备薄层色谱等方法分离纯化化合物,通过波谱数据和理化性质鉴定结构。结果:从沙煲暗罗根中得到10个化合物:5,7-二羟基-8-甲酰基-6-甲基黄烷酮(1),demethoxymatteucinol(2),5,7-二羟基-6-甲基-8-甲酰基黄酮(3),5,7-二羟基-6-甲酰基-8-甲基黄酮(4),MarcanineA(5),suberosol(6),β-谷甾醇(7),香草醛(8),肉桂酸(9),烟酸(10)。结论:化合物1-4为首次从该属中分离得到,所有化合物为首次从该植物中分离得到。化合物6对人肿瘤细胞SPC-A-1和SGC-7901显示有细胞毒性。AIM： To study the chemical constituents from the roots of Polyalthia obliqua. METHODS： The constituents were isolated and purified by silica gel column chromatography, Sephadex LH-20 and preparative TLC. Their structures were identified on the basis of spectral data and physiochemical properties. RESULTS： Ten compounds were isolated and their structures were elucidated as 5,7-dihydroxy-8-formyl-6-methylflavanone （1）, demethoxymatteucin ol （2）, 5,7-dihydroxy-6-methyl-8-formylflavone （3）, 5, 7-dihy- droxy-6-formyl-8-methylflavone （4）, marcanine A （5）, suberosol （6）, β-sitosteral （7）, vanillin （8）, cinnamic acid （9） and nicotinic acid （10）. CONCLUSION： Compounds 1-4 were reported from the genus for the first time. All the compounds were isolated from this plant for the first time. Compound 6 showed cytotoxicity against human cancer cell lines SPC-A-1 and SGC-7901.

关 键 词：沙煲暗罗根 化学成分 细胞毒性 

分 类 号：R284.1[医药卫生—中药学] R965[医药卫生—中医学]