肠出血性大肠杆菌Ⅲ型分泌系统调控因素的研究进展  

Development of Regulation Factor of Type Ⅲ Secretion Systems in Enterohaemorrhagic Escherichia coli

作　　者：魏波[1,2] 刘明强[1] 呼和巴特尔[1] 

机构地区：[1]内蒙古农业大学兽医学院,内蒙古呼和浩特010018 [2]中国人民解放军军事医学科学院,北京100071

出　　处：《中国畜牧兽医》2012年第6期161-164,共4页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然基金(C40620610)

摘　　要：Ⅲ型分泌系统(TyprⅢsecretion system,T3SS)是一种将细菌蛋白通过膜屏障注入宿主细胞的装置,Ⅲ型分泌系统(T3SS)是肠出血性大肠杆菌定植反刍动物储存宿主所必需的,也是引起人致病的重要原因之一。E.coli注射蛋白质进入上皮细胞使得细菌可以黏附并且促使其长时间定植在动物体内。在此,对关于EHECⅢ型分泌系统调控的研究近况、效应蛋白表达的共调控进行了综述。Type Ⅲ secretion systems （T3SS） enable the injection of bacterial proteins through membrane barriers into host cells. This system is required for colonization of their ruminant reservoir hosts by enterohaemorrhagic Escherichia coli （EHEC） and might also be important for the etiology of disease in the incidental human host. T3SS of E. coli inject a cocktail of proteins into epithelial cells that enable bacterial attachment and promotes longer-term colonization in the animal. Here, we review recent progress in our understanding of the regulation of T3SS in EHEC, focusing on the induction and assembly of the T3SS, and the co-ordination of effector protein expression.

关 键 词：肠出血性大肠杆菌 Ⅲ型分泌系统 效应蛋白 

分 类 号：S852.61[农业科学—基础兽医学]