垂体促性腺激素表达的受体后信号转导机制  

The Post-receptor Signal Transduction Mechanism of the Expression of GTH

作　　者：王新[1,2] 

机构地区：[1]青岛农业大学动物科学技术学院,山东青岛266109 [2]广州中医药大学中药学院,广东广州510006

出　　处：《中国畜牧兽医》2012年第6期224-227,共4页China Animal Husbandry & Veterinary Medicine

基　　金：青岛农业大学高层次人才启动基金(630810);青岛农业大学实验技术课题(SYJK09-05);青岛农业大学教学研究课题(XJG0906);国家自然科学基金(30571356);广州中医药大学博士后科研资助金(B3YH1008);广东省科技计划项目(2011B050300021)

摘　　要：对促性腺激素释放激素(GnRH)作用机制的研究是一个重要领域。文章综述了国内外GnRH的研究进展,认为GnRH与受体(Rs)结合后,要通过一系列的信号转导,调节和控制促卵泡激素(FSH)和黄体生成素(LH)的合成和分泌。Gn-RH受体后信号转导途径主要是通过3大信号转导系统完成的:环磷酸腺苷(cAMP)信号转导系统、蛋白激酶C(PKC)信号转导系统和丝裂原活化蛋白激酶(MAPK)信号转导系统。cAMP信号转导通路和PKC信号转导通路都属于G蛋白偶联的信号通路,二者最后都要通过激活MAPK信号转导系统来完成调控。这为进一步研究GnRH作用机制提供了依据,同时讨论了存在的问题,并对下一步的研究方向做出展望。It is an important area of research on the mechanism of gonadotropin-releasing hormone, The paper reviews the domestic and foreign advances on GnRH and think GnRH regulates the synthesis and secretion of FSH and LH after binding its receptor in a series of signal transduction. The GnRH post-receptor signal transduction pathway may consist of three major sig- nal transduction system： the cAMP signal transduction system, PKC signal transduction system and MAPK signal transduc- tion system, cAMP signal transduction pathway and PKC signal transduction pathway belong to G protein coupling signaling pathways, who both finish regulation by activating MAPK signal transduction system at last. It provides the base on the fur- ther study, some suggestions gived on existents problems and further research direction raised.

关 键 词：促性腺激素 信号转导系统 受体后 

分 类 号：Q422[生物学—神经生物学]