微波辐射下吡喃并[3,2-c]吡啶酮和吡喃并[4,3-b]吡喃酮类化合物的高效绿色合成  

The Efficient and Green Syntheses of Pyrano [3,2-c] pyridine and Pyrano [4,3-b] pyran Derivatives under Microwave Irradiation

作　　者：徐海云[1] 黄文华[1,2] 李淑昱[1] 张新迎[1] 

机构地区：[1]河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡453007 [2]永城职业学院,河南永城476600

出　　处：《化学通报》2012年第6期532-539,共8页Chemistry

基　　金：国家自然科学基金项目(20972042);河南省科技创新人才杰出青年基金项目(104100510019);国家大学生创新性实验计划项目(091047620)资助

摘　　要：对离子液体介质中微波辐射下芳香醛、吡啶(喃)酮和丙二腈的三组分缩合反应的研究发现,该反应可快速完成,无需使用催化剂,并以较高的收率生成相应的吡喃并[3,2-c]吡啶酮和吡喃并[4,3-b]吡喃酮类化合物。与文献方法相比,该方法具有反应速度快、效率高、原料易得、对环境友好等优点。另外,该方法已成功地应用于吡喃并[3,2-c]吡啶酮和吡喃并[4,3-b]吡喃酮-嘧啶核苷杂化体的合成中。A series of pyrano [3,2-c] pyridone and pyrano [4,3-b] pyran derivatives were synthesized efficiently by three-component reaction of aldehydes,4-hydroxy-pyridin-2-（1H）-one or 4-hydroxy-2-pyranone and malononitrile in BF4 under microwave irradiation without any catalyst.The reactions were rapid,enhanced efficiency,and environmentally benign,and the starting materials of the reactions were readily available.In addition,the procedure was successfully applied to the preparation of pyrimidine nucleoside hybrids of pyranopyridone or pyrano [4,3-b]-pyran.

关 键 词：吡喃并[3 2-c]吡啶酮 吡喃并[4 3-b]吡喃酮 嘧啶核苷 微波辐射 离子液体 

分 类 号：O626.32[理学—有机化学]