新型尾式多肽卟啉的合成与光谱性质研究  

Synthesis and Spectral Properties of Novel Tailed Porphrin Polypeptides

作　　者：薛珺 曾婷 王亚军 罗国添[1,2] 

机构地区：[1]赣南师范学院化学化工学院,赣州341000 [2]江西省有机药物化学重点实验室,赣州341000

出　　处：《化学通报》2012年第6期547-551,共5页Chemistry

基　　金：国家自然科学基金项目(20761001;21161001);江西省教育厅科技基金项目(GJJ11588)资助

摘　　要：以5-(4-氨基苯基)-10,15,20-三苯基卟啉和叔丁氧羰基(Boc)保护的氨基酸为原料,合成了3种新型尾式多肽卟啉。通过FT-IR,FAB-MS,1H NMR,UV-Vis及元素分析对产物进行了表征并研究了其光谱性质。结果表明,所合成的尾式多肽卟啉产率高达90%以上,在位于可见光红光区的650nm附近均具有较强的荧光发射,符合光敏剂在光学方面的要求,有望成为新型潜在的具有靶向作用的光敏剂。Three novel tailed porphyrin polypeptides were designed and synthesized by the reaction of 5-（4-aminophenyl）-10,15,20-triphenylporphyrin with amino acids protected with tert-butoxycarbonyl（Boc）.The as-prepared compounds were characterized by FT-IR,FAB-MS,1H NMR,UV-Vis and element analysis.The products exhibited strong fluorescence emit at near 650 nm.That means they meet the requirements of photosensitizer used in the optical field,and is expected to become a potential targeting photosensitizer.

关 键 词：尾式多肽卟啉 合成 光谱性质 

分 类 号：O626[理学—有机化学]