侧柏叶不同提取液的成膜材料筛选  

Screening of Film Forming Material for Different Extraction Liquid of Platycladus orientalis Leaf

作　　者：刘东辉[1] 石添香[1] 何坦 罗明[1] 魏刚[1] 许日鑫[1] 

机构地区：[1]广州中医药大学,广州510006 [2]广州中一药业有限公司,广州510130

出　　处：《中国实验方剂学杂志》2012年第12期9-14,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部"十一五"科技支撑计划项目(2008BAI53B074);广东高校科技成果转化重大项目(cgzhzd1009)

摘　　要：目的:考察主要成膜材料在侧柏叶水提液及不同体积分数乙醇提取液中的成膜性能,为含侧柏叶的中药喷膜剂的成膜材料选择与应用提供参考。方法:根据成膜材料的溶解性,选择聚乙烯吡咯烷酮(PVP),聚乙烯醇(PVA),乙基纤维素(EC),甲基纤维素(MC)等成膜材料,通过显微镜和图像拍摄软件对膜结构拍照分析,考察各成膜材料在侧柏叶水提液和不同体积分数乙醇提取液中的成膜性能。结果:PVP-K30,PVP-K90在侧柏叶水提液以及不同体积分数乙醇提取液中具有良好的成膜性;PVA在侧柏叶水提液及体积分数为20%,40%,60%的乙醇溶液中均能成膜,但膜表面凹凸不平、较粗糙;EC在侧柏叶无水乙醇提取液中成膜性能优良,但在侧柏叶80%乙醇提取液中成膜性则较差,膜结构较不明显;MC在侧柏叶的水提液和不同体积分数乙醇提取液中成膜性较好,能形成一层细密、厚实的膜;PVB只在侧柏叶无水乙醇提取液中成膜性较为优良。结论:成膜材料的选择与侧柏叶提取液溶媒的极性相关;PVP-K30在侧柏叶的水提和不同体积分数乙醇提取液中成膜性均较好,是含侧柏叶的中药喷膜剂、膜剂等的成膜材料的最优选择。Objective： To investigate film-forming properties of main film-forming materials in water extraction liquid and different concentration ethanol extraction liquid of Platycladus orientalis leaf, then to provide references for selection and application of film-forming material from Chinese medicine spray membrane agent containing P. orientalis leaf. Method： According to solubility of film-forming material, polyvinylpyrrolidone （PVP）, polyVinyl alcohol （PVA）, ethyl cellulose （EC） and methyl cellulose （MC） were selected as film- forming materials, membrane structure photos was analyzed by microscopy and image capture software, film- forming property of film-forming materials was investigated in water extraction liquid and different concentration ethanol extraction liquid of P. orientalis leaf. Result： Film-forming properties of PVP-K30 and PYP-Kg0 in water extraction liquid and different concentration ethanol extraction liquid of P. orientalis leaf was very fine; PVA in water extraction liquid and the concentration of 20% , 40% , 60% ethanol extraction liquid could form film, but surface of membrane was uneven and rough; Film-forming property of EC in extraction solution of 100% ethanol was very fine, but it was poor in extraction solution of 80% ethanol, membrane structure was not obvious; Film- forming properties of MC in water extraction liquid and different concentration ethanol extraction liquid of P. orientalis leaf were very well, it could form a layer of thick and dense film; Film-forming property of PVB was excellent only in extraction solution of 100% ethanol. Conclusion： Choice of film-forming material had a relationship with polarity of extraction solvent for extraction liquid of P. orientalis leaf; Film-forming properties of PVP-K30 were fine in water extraction liquid and different concentration ethanol extraction liquid of P. orientalis leaf, it was optimum choice of film-forming material for Chinese medicine spray film agent and film agent containing P. orientalis leaf.

关 键 词：侧柏叶 提取液 成膜材料 成膜性能 PVP—K30 

分 类 号：R283.6[医药卫生—中药学]