三黄喷雾剂体外透皮吸收  

Transdermal Absorption of Sanhuang Spray in vitro

作　　者：朱鹏飞[1] 冯伟红[2] 杜茂波[2] 王洪珍[3] 李颖[3] 刘树扬[1] 吴志成[2] 刘淑芝[2] 

机构地区：[1]首都医科大学,北京100069 [2]中国中医科学院中药研究所,北京100700 [3]通化万通药业股份有限公司,吉林通化134001

出　　处：《中国实验方剂学杂志》2012年第12期15-17,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制项目(2009ZX09502-010;2009ZX09301-005-05);中国中医科学院自主选题项目(Z02094)

摘　　要：目的:考察三黄喷雾剂小鼠体外经皮渗透规律。方法:采用垂直式改良Franz扩散池装置进行试验,以黄芩苷和盐酸小檗碱含量为考察指标,HPLC测定接受液中指标成分含量。结果:黄芩苷、盐酸小檗碱的透皮速率分别为42.35,49.99μg.cm-2.h-1;黄芩苷、盐酸小檗碱6 h平均累积透过率分别为19.51%,7.17%。结论:三黄喷雾剂小鼠体外透皮吸收效果理想,透皮行为符合零级方程。Objective： To investigate in vitro percutaneous penetration law of Sanhuang spray in mice. Method： Vertical modified Franz diffusion cell device was used with the content of baicalin and berberine hydrochloride as indexes, index ingredients in receiving liquid were determined by HPLC. Result： Transdermal rates of baicalin and berberine hydrochloride were 42.35, 49.99 μg·cm^-2·h^-1, respectively; Average cumulative penetration rate of baicalin and berberine hydrochloride in 6 h were 19.51% , 7.17% , respectively. Conclusion： In vitro transdermal absorption effect in mice of Sanhuang spray was ideal, transdermal behavior was in accordance with zero-level equation.

关 键 词：三黄喷雾剂 透皮吸收 黄芩苷 盐酸小檗碱 

分 类 号：R283.6[医药卫生—中药学]