鸦胆子油自微乳的体外释放度考察  

Investigation of in vitro Release Rate of Brucea javanica Oil Self-microemulsion

作　　者：孔繁晟[1] 严春艳[1] 贲永光[1] 李淡霞[1] 邵阿丽[1] 

机构地区：[1]广东药学院药科学院,广州510006

出　　处：《中国实验方剂学杂志》2012年第12期21-23,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81102779);广东省自然科学基金项目(9451022401003453)

摘　　要：目的:建立鸦胆子油自微乳溶出度的测定方法。方法:采用气相色谱法测定鸦胆子油中油酸的含量,以确定鸦胆子油自微乳化制剂溶出度测定的最佳条件。色谱条件为DB-FFAP毛细管柱(0.25 mm×30 m,0.25μm),进样口温度220℃,检测器温度220℃,柱温205℃,进样量1μL。以0.1 mol.L-1HCl为溶出介质,硬胶囊壳为载体,转篮法测定鸦胆子油自微乳化给药系统的体外溶出度。结果:鸦胆子油自微乳累积溶出度在15 min达90%。结论:该测定方法准确可靠,可用于鸦胆子油自微乳的质量控制。Objective： To establish determination method of in virto release of Brucea javanica oil self- microemulsion. Method： The content of oleic acid from B. javanica oil was determined by GC method, to determine optimum conditions of dissolution determination of B. javanica oil self-microemulsion. Chromatographic conditions were： DB-FFAP capillary column （0.25 mm × 30 m, 0.25 μm） , column temperature of 205 ℃ , temperture of inlet and detector were 220 ℃, sample volume 1 μL. 0. 1 mol · L^-1 HC1 as dissolution medium, hard capsule shell as a carrier, in vitro release of B. javanica oil self-microemulsion drug delivery system was determined by rotating basket method. Result： Cumulative dissolution of B. javanica oil self-microemulsion was 90% in 15 min. Conclusion： This determination method was accurate and reliable, and it could be used for quality control of B. javanica oil self-microemulsion.

关 键 词：鸦胆子油 自微乳化给药系统 溶出度 气相色谱法 

分 类 号：R283.6[医药卫生—中药学]